Clinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross-sectional, multicentre study of 263 patients

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dc.contributor.authorSarıkaya Solak S.
dc.contributor.authorKara Polat A.
dc.contributor.authorKilic S.
dc.contributor.authorOguz Topal İ.
dc.contributor.authorSaricaoglu H.
dc.contributor.authorKaradag A.S.
dc.contributor.authorCanpolat F.
dc.contributor.authorKartal S.P.
dc.contributor.authorDeveci B.N.
dc.contributor.authorKacar N.
dc.contributor.authorPolat Ekinci A.
dc.contributor.authorGuner R.
dc.contributor.authorPolat M.
dc.contributor.authorDogan G.
dc.contributor.authorGuler Ozden M.
dc.contributor.authorBulbul Baskan E.
dc.contributor.authorOzaydin Yavuz G.
dc.contributor.authorAdisen E.
dc.contributor.authorGulekon A.
dc.contributor.authorTanribilir M.E.
dc.contributor.authorYilmaz O.
dc.contributor.authorAkman Karakas A.
dc.contributor.authorOzturk P.
dc.contributor.authorDidar Balci D.
dc.contributor.authorGonulal M.
dc.contributor.authorYondem H.
dc.contributor.authorTurel Ermertcan A.
dc.contributor.authorSendur N.
dc.contributor.authorTopyildiz H.
dc.contributor.authorKorkmaz S.
dc.contributor.authorAlpsoy E.
dc.date.accessioned2024-07-22T08:05:15Z
dc.date.available2024-07-22T08:05:15Z
dc.date.issued2022
dc.description.abstractBackground: Palmoplantar pustulosis (PPP) is a rare, chronic, inflammatory skin disease characterized by sterile pustules on palmar or plantar areas. Data on PPP are scarce. Aim: To investigate the clinical characteristics and risk factors for disease severity in a large cohort of Turkish patients with PPP. Methods: We conducted a cross-sectional, multicentre study of patients with PPP recruited from 21 tertiary centres across Turkey. Results: In total, 263 patients (165 women, 98 men) were evaluated. Most patients (75.6%) were former or current smokers. The mean Palmoplantar Pustulosis Area and Severity Index (PPPASI) was 8.70 ± 8.06 and the mean Dermatology Life Quality Index (DLQI) score was 6.87 ± 6.08, and these scores were significantly correlated (r = 0.52, P < 0.001). Regression analysis showed that current smoking was significantly associated with increased PPPASI (P = 0.03). Coexisting psoriasis vulgaris (PsV) was reported by 70 (26.6%) patients. Male sex prevalence, PPP onset incidence, disease duration, DLQI, and prevalence of nail involvement and psoriatic arthritis (PsA) were significantly increased among patients with PPP with PsV. Of the 263 patients, 18 (6.8%) had paradoxical PPP induced by biologic therapy, and these patients had significantly increased mean DLQI and prevalence of PsA (r = 0.03, P = 0.001). Conclusion: Our data suggest that smoking is a risk factor for both PPP development and disease severity. Patients with PPP with PsV present distinct clinical features and patients with biologic therapy-induced paradoxical PPP have reduced quality of life and are more likely to have PsA. © 2021 British Association of Dermatologists.
dc.identifier.DOI-ID10.1111/ced.14829
dc.identifier.issn03076938
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13064
dc.language.isoEnglish
dc.publisherJohn Wiley and Sons Inc
dc.subjectAdult
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectFoot Dermatoses
dc.subjectHand Dermatoses
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrevalence
dc.subjectProspective Studies
dc.subjectPsoriasis
dc.subjectQuality of Life
dc.subjectRisk Factors
dc.subjectSeverity of Illness Index
dc.subjectTurkey
dc.subjectC reactive protein
dc.subjectadult
dc.subjectArticle
dc.subjectatrial fibrillation
dc.subjectclinical feature
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectDermatology Life Quality Index
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmulticenter study
dc.subjectPalmoplantar Pustulosis Area Severity Index
dc.subjectprevalence
dc.subjectprospective study
dc.subjectpustulosis palmoplantaris
dc.subjectquality of life
dc.subjectrisk factor
dc.subjectsmoking
dc.subjectTurk (people)
dc.subjectclinical trial
dc.subjecthand disease
dc.subjectpsoriasis
dc.subjectrisk factor
dc.subjectseverity of illness index
dc.subjectskin disease
dc.subjectturkey (bird)
dc.titleClinical characteristics, quality of life and risk factors for severity in palmoplantar pustulosis: a cross-sectional, multicentre study of 263 patients
dc.typeArticle

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