Etiology and outcome of acute kidney injury in children

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dc.contributor.authorDuzova A.
dc.contributor.authorBakkaloglu A.
dc.contributor.authorKalyoncu M.
dc.contributor.authorPoyrazoglu H.
dc.contributor.authorDelibas A.
dc.contributor.authorOzkaya O.
dc.contributor.authorPeru H.
dc.contributor.authorAlpay H.
dc.contributor.authorSoylemezoglu O.
dc.contributor.authorGur-Guven A.
dc.contributor.authorBak M.
dc.contributor.authorBircan Z.
dc.contributor.authorCengiz N.
dc.contributor.authorAkil I.
dc.contributor.authorOzcakar B.
dc.contributor.authorUncu N.
dc.contributor.authorKarabay-Bayazit A.
dc.contributor.authorSonmez F.
dc.date.accessioned2024-07-22T08:20:44Z
dc.date.available2024-07-22T08:20:44Z
dc.date.issued2010
dc.description.abstractThe aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged>1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged>1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged>1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p<0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged >1 month. © 2010 IPNA.
dc.identifier.DOI-ID10.1007/s00467-010-1541-y
dc.identifier.issn0931041X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18282
dc.language.isoEnglish
dc.subjectChild
dc.subjectFemale
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectKidney
dc.subjectKidney Failure, Acute
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectRespiration, Artificial
dc.subjectRisk Factors
dc.subjectSepsis
dc.subjectTreatment Outcome
dc.subjectarticle
dc.subjectartificial ventilation
dc.subjectcausal attribution
dc.subjectchild
dc.subjectchildhood disease
dc.subjectcongenital heart disease
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectinfant
dc.subjectkidney injury
dc.subjectkidney ischemia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant neoplastic disease
dc.subjectmetabolic acidosis
dc.subjectmortality
dc.subjectnewborn
dc.subjectnewborn mortality
dc.subjectprematurity
dc.subjectpriority journal
dc.subjectsepsis
dc.subjectacute kidney failure
dc.subjectkidney
dc.subjectmortality
dc.subjectmultivariate analysis
dc.subjectrisk factor
dc.subjecttreatment outcome
dc.titleEtiology and outcome of acute kidney injury in children
dc.typeArticle

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