A study on photophysical properties of some Vitamin K3 derivatives

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dc.contributor.authorHakli O.
dc.contributor.authorKarapire C.
dc.contributor.authorPosokhov Y.
dc.contributor.authorIçli S.
dc.date.accessioned2024-07-22T08:24:33Z
dc.date.available2024-07-22T08:24:33Z
dc.date.issued2004
dc.description.abstractPhotophysical properties of menadione sodium bisulfite (MSB), menadione nicotinamide bisulfite (MNB) and menadione dimethylpyrimidinol bisulfite (MPB) were studied in their aqueous solutions. They are oil-soluble vitamins and not naturally fluorescent, however, it is possible to gain fluorescent signal by the use of phosphate buffer solutions containing sodium dodecyl sulfate (SDS) at optimum concentration. The quantum yields of fluorescence emission, Φ f, were measured as ∼10-4, 0.0085 and 0.053 for MSB, MNB, MPB, respectively. Fluorescence quenching with Co2+ ions yielded the quenching rates of 1.7×109, 4.6×1010, and 1.5×1010 M-1 s-1 for MSB, MNB and MPB, respectively. Calculated Gibbs free energy (Δ G) values (≤-5 kcal/mol) of the compounds suggest that electron transfer could be the reason of quenching with Co2+ ions. Studied derivatives were found to give two electrons. Equilibrium constants (Keq) derived from Δ G values pointed out strong association between the pairs of MSB, MNB and MPB complexes. They were irradiated by using not only artificial Xe lamp of fluorescence spectrophotometer, but also by using direct and concentrated sunlight and degradation (%), rate constant (kp) and half-lives (t1/2) were compared. Photodegradation (%) of Vitamin K3 derivatives varied depending on the irradiation source. Photostability tests pointed out MPB as the most stable derivative. © 2004 Elsevier B.V. All rights reserved.
dc.identifier.DOI-ID10.1016/S1010-6030(03)00384-8
dc.identifier.issn10106030
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20022
dc.language.isoEnglish
dc.subjectbuffer
dc.subjectdodecyl sulfate sodium
dc.subjectmenadione
dc.subjectmenadione dimethylpyrimidinol bisulfite
dc.subjectmenadione nicotinamide bisulfite
dc.subjectmenadione sodium bisulfite
dc.subjectphosphate
dc.subjectunclassified drug
dc.subjectxenon
dc.subjectaqueous solution
dc.subjectarticle
dc.subjectcalculation
dc.subjectcomplex formation
dc.subjectconcentration (parameters)
dc.subjectcontrolled study
dc.subjectdrug degradation
dc.subjectdrug half life
dc.subjectdrug solubility
dc.subjectdrug stability
dc.subjectdrug structure
dc.subjectelectron transport
dc.subjectenergy yield
dc.subjectequilibrium constant
dc.subjectirradiation
dc.subjectphotochemical quenching
dc.subjectphotochemistry
dc.subjectphotodegradation
dc.subjectquantum yield
dc.subjectspectrofluorometry
dc.subjectsunlight
dc.titleA study on photophysical properties of some Vitamin K3 derivatives
dc.typeArticle

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