Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis

Simple item page
dc.contributor.authorBourne C.
dc.contributor.authorAydemir O.
dc.contributor.authorBalanzá-Martínez V.
dc.contributor.authorBora E.
dc.contributor.authorBrissos S.
dc.contributor.authorCavanagh J.T.O.
dc.contributor.authorClark L.
dc.contributor.authorCubukcuoglu Z.
dc.contributor.authorDias V.V.
dc.contributor.authorDittmann S.
dc.contributor.authorFerrier I.N.
dc.contributor.authorFleck D.E.
dc.contributor.authorFrangou S.
dc.contributor.authorGallagher P.
dc.contributor.authorJones L.
dc.contributor.authorKieseppä T.
dc.contributor.authorMartínez-Aran A.
dc.contributor.authorMelle I.
dc.contributor.authorMoore P.B.
dc.contributor.authorMur M.
dc.contributor.authorPfennig A.
dc.contributor.authorRaust A.
dc.contributor.authorSenturk V.
dc.contributor.authorSimonsen C.
dc.contributor.authorSmith D.J.
dc.contributor.authorBio D.S.
dc.contributor.authorSoeiro-de-Souza M.G.
dc.contributor.authorStoddart S.D.R.
dc.contributor.authorSundet K.
dc.contributor.authorSzöke A.
dc.contributor.authorThompson J.M.
dc.contributor.authorTorrent C.
dc.contributor.authorZalla T.
dc.contributor.authorCraddock N.
dc.contributor.authorAndreassen O.A.
dc.contributor.authorLeboyer M.
dc.contributor.authorVieta E.
dc.contributor.authorBauer M.
dc.contributor.authorWorhunsky P.D.
dc.contributor.authorTzagarakis C.
dc.contributor.authorRogers R.D.
dc.contributor.authorGeddes J.R.
dc.contributor.authorGoodwin G.M.
dc.date.accessioned2024-07-22T08:18:13Z
dc.date.available2024-07-22T08:18:13Z
dc.date.issued2013
dc.description.abstractObjective: An association between bipolar disorder and cognitive impairment has repeatedly been described, even for euthymic patients. Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view. Method: Individual patient and control data were obtained from original authors for 11 measures from four common neuropsychological tests: California or Rey Verbal Learning Task (VLT), Trail Making Test (TMT), Digit Span and/or Wisconsin Card Sorting Task. Results: Impairments were found for all 11 test-measures in the bipolar group after controlling for age, IQ and gender (Ps ≤ 0.001, E.S. = 0.26-0.63). Residual mood symptoms confound this result but cannot account for the effect sizes found. Impairments also seem unrelated to drug treatment. Some test-measures were weakly correlated with illness severity measures suggesting that some impairments may track illness progression. Conclusion: This reanalysis supports VLT, Digit Span and TMT as robust measures of cognitive impairments in bipolar disorder patients. The heterogeneity of some test results explains previous differences in meta-analyses. Better controlling for confounds suggests deficits may be smaller than previously reported but should be tracked longitudinally across illness progression and treatment. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.identifier.DOI-ID10.1111/acps.12133
dc.identifier.issn16000447
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17237
dc.language.isoEnglish
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAffect
dc.subjectAffective Symptoms
dc.subjectAge of Onset
dc.subjectBipolar Disorder
dc.subjectCognition Disorders
dc.subjectConfounding Factors (Epidemiology)
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMental Competency
dc.subjectMental Processes
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectPsychiatric Status Rating Scales
dc.subjectPsychotropic Drugs
dc.subjectRisk Factors
dc.subjectbipolar disorder
dc.subjectcognitive impairment
dc.subjectneuropsychological tests
dc.subjectreview
dc.subjectanticonvulsive agent
dc.subjectantidepressant agent
dc.subjectlithium
dc.subjectneuroleptic agent
dc.subjectage
dc.subjectarticle
dc.subjectbipolar disorder
dc.subjectcognitive defect
dc.subjectdisease association
dc.subjectdisease severity
dc.subjecteuthymic bipolar disorder
dc.subjectexecutive function
dc.subjectgender
dc.subjecthuman
dc.subjectintelligence quotient
dc.subjectlearning
dc.subjectmemory
dc.subjectmeta analysis
dc.subjectnamed inventories, questionnaires and rating scales
dc.subjectneuropsychological test
dc.subjectpatient coding
dc.subjectpriority journal
dc.subjectpsychologic test
dc.subjectreverse digit span
dc.subjecttask performance
dc.subjectTrail Making Test B
dc.subjectWechsler Intelligence Scale
dc.subjectWechsler Memory Scale
dc.subjectWisconsin Card Sorting Test
dc.titleNeuropsychological testing of cognitive impairment in euthymic bipolar disorder: An individual patient data meta-analysis
dc.typeArticle

Files

Collections

Scopus Koleksiyonu