The effects of meloxicam on neural tube development in the early stage of chick embryos; [Meloksikamın erken dönem civciv embriyosunda nöral tüp geliflimine etkileri]

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dc.contributor.authorCetinkal A.
dc.contributor.authorColak A.
dc.contributor.authorTopuz K.
dc.contributor.authorDemircan M.N.
dc.contributor.authorSimsek H.
dc.contributor.authorBerber U.
dc.contributor.authorUmur A.S.
dc.contributor.authorSelcuki M.
dc.contributor.authorVatansever H.S.
dc.date.accessioned2024-07-22T08:21:13Z
dc.date.available2024-07-22T08:21:13Z
dc.date.issued2010
dc.description.abstractAIM: The aim of this study is to demonstrate the effect of meloxicam in early stage chick embryos on neural tube development. MATERIAL and METHODS: One hundred specific pathogen-free (SPF) chicken eggs were used to investigate the neurulation. SPF eggs were invastigated in four groups (n:25). All of the groups were incubated at 37.2 ± 0.1°C and 60 ± 5 % relative humidity for 30 hours, and an embryological development in the ninth stage as classified by Hamburger and Hamilton was obtained. In the end of the 30th hour, group A(control group) was administered 0.1 ml of saline (0.9% NaCl) in ovo and the other groups were administered meloxicam in increasing doses. At the end of 72 hours, all of the embryos were extracted from eggs and they underwent pathological examination with hematoxylin eosine and immunohistopathological examinations with CD138 and tubulin beta II. RESULTS: While the groups Aand B showed no neural tube defects, totally eight defective embryos were detected in the groups C and D (three in group C and five in group D. CONCLUSION: Our results suggested that meloxicam, a nonselective COX inhibitor, caused neural tube closure defects when injected at supratherapeutic doses. However, further studies with larger numbers of subjects are needed for its use in lower doses.
dc.identifier.issn10195149
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18514
dc.language.isoTurkish
dc.publisherTurkish Neurosurgical Society
dc.subjectAnimals
dc.subjectChick Embryo
dc.subjectChickens
dc.subjectCyclooxygenase Inhibitors
dc.subjectDose-Response Relationship, Drug
dc.subjectImmunohistochemistry
dc.subjectNeural Tube
dc.subjectNeural Tube Defects
dc.subjectSyndecan-1
dc.subjectThiazines
dc.subjectThiazoles
dc.subjectTubulin
dc.subjectmeloxicam
dc.subjectprostaglandin synthase inhibitor
dc.subjectsyndecan 1
dc.subjectthiazine derivative
dc.subjectthiazole derivative
dc.subjecttubulin
dc.subjectanimal
dc.subjectchemically induced
dc.subjectchick embryo
dc.subjectchicken
dc.subjectdose response
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectneural tube
dc.subjectneural tube defect
dc.subjectpathology
dc.subjecttoxicity
dc.titleThe effects of meloxicam on neural tube development in the early stage of chick embryos; [Meloksikamın erken dönem civciv embriyosunda nöral tüp geliflimine etkileri]
dc.typeArticle

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