Browsing by Author "Özbakkaloǧlu B."

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    Relationship between pinworm and urinary tract infections in young girls
    (Blackwell Munksgaard, 1999) Ok U.Z.; Ertan P.; Limoncu E.; Ece A.; Özbakkaloǧlu B.
    Urinary tract infection is particularly common in young girls and Enterobius vermicularis (pinworm) is one of the most prevalent worms found in children worldwide. Young girls, with or without urinary tract infection, were examined for pinworms in order to explore a possible relationship between these two problems. Of the 55 young girls with urinary tract infection, 20 (36.4%) had pinworm eggs in the perianal and/or perineal region monitored using the cellophane tape method, while 9 (16.4%) of 55 young girls who had never previously had a urinary tract infection were found to have Enterobius eggs in at least one of the cellophane tape tests, and the difference was found to be significant (p<0.05). These results suggested that urinary tract infections may be related to pinworms. When a urinary tract infection is diagnosed in young girls, cellulose tape should be applied to both the perianal and the perineal regions on at least three consecutive occasions.
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    Granulomatous hepatitis following intravesical bacillus Calmette-Guerin therapy
    (1999) Özbakkaloǧlu B.; Tünger Ö.; Sürücüoǧlu S.; Lekili M.; Kandiloglu A.R.
    Although intravesical bacillus Calmette-Guerin (BCG) administration is an effective method in the treatment of superficial urinary bladder carcinoma, some complications may arise such as a granulomatous reaction either in the urinary tract or, in rare cases, outside the urinary tract. We report in this paper a case of granulomatous hepatitis following intravesical BCG administration.
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    Extended spectrum beta-lactamase production and susceptibility to antibiotics in Escherichia coli strains isolated from community acquired and nosocomial infections; [Toplum kökenli̇ ve nozokomi̇yal i̇drar yolu enfeksi̇yonlarindan i̇zole edi̇len Escherichia coli suşlarinda geni̇şlemi̇ş spektrumlu beta-laktamaz varliǧinin araştirilmasi ve çeşi̇tli̇ anti̇bi̇yoti̇klere duyarliliklari]
    (2001) Tünger Ö.; Sürücüoǧlu S.; Özbakkaloǧlu B.; Gazí H.
    This study was planned to determine the extended spectrum beta-Lactamase (ESBL) production and antibiotic susceptibility of Escherichia coli strains isolated from patients with nosocomial and community acquired urinary tract infections. A total of 218 E. coli strains isolated from 126 community acquired and 92 nosocomial urinary tract infections were included to the study and ESBL production was investigated by double disk synergy method. ESBL positivity rates of isolates from patients with community acquired and nosocomial urinary tract infections were found to be as 3.9% and 9.8%, respectively (p<0.05). Susceptibility to amikacin, amoxicillin/clavulanate, aztreonam, gentamicin, imipenem, netilmicin, ofloxacin, piperacillin, cephalotin, cefepime, ceftazidime, ceftriaxone, cefuroxime, ciprofloxacin, trimethoprim/sulfamethoxazole was investigated by disk diffusion method, and although the resistance rates to these antimicrobials were found higher in nosocomial strains than those community strains, the differences were statistically insignificant, except for gentamicin.
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    Secondary Brucellar psoas abscess
    (2002) Tünger Ö.; Arýsoy A.S.; Özbakkaloǧlu B.; Temiz C.; Borand H.
    PSOAS ABSCESSES are rarely seen and usually misdiagnosed infections of the musculoskeletal system. A case of secondary psoas abscess due to Brucella spp. that was successfully treated with percutaneous computed tomography-guided aspiration and antimicrobial therapy is presented. The reported cases, diagnostic and therapeutic recommendations are also reviewed.
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    Nurses' knowledge regarding patients with intravenous catheters and phlebitis interventions
    (Mosby Inc., 2003) Karadeniz G.; Kutlu N.; Tatlisumak E.; Özbakkaloǧlu B.
    This study was planned and applied in 2 stages. Stage I was applied to determine the knowledge of nurses working in the internal medicine, surgery, obstetrics and gynecology, pediatrics, and other services in Celal Bayar University Hospital about using intravenous catheter and intravenous fluid treatment, and the symptoms and treatment procedure for phlebitis. Stage II consisted of observation of all patients who had intravenous catheters for symptoms of phlebitis for 5 days and the interventions the nurses used for the patients who had phlebitis. In stage I, questionnaires were used to determine the knowledge of the nurses; in stage II, 2 investigators observed the patients. Results were evaluated using SPSS software with χ2 statistical analysis. Nurses were found to have high knowledge levels, but their practices were not suitable to their knowledge levels. Of the patients who participated in the study, 67.24% showed symptoms of phlebitis. We found that there was a significant relationship (P < .05) between the selection of the vein and the occurrence of phlebitis in patients who had an intravenous catheter. We also found that the relationships between the age groups of the patients and phlebitis and the relationships between the diagnosis and phlebitis were statistically significant (P < .05).
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    Effects of Different Disinfectants on Decontamination of Laryngoscopes; [Laringoskoplarin Dezenfeksiyonunda Kullanilan Dezenfektanlarin Etkinliǧinin Karşilaştirilmasi]
    (2003) Tekin I.; Arican I.; Akçali S.; Şanlidaǧ T.; Özbakkaloǧlu B.
    Guidelines for controlling possible contamination of laryngoscopes should be formulated with the benefit of relevant experimental data. In this study, the effects of five different disinfectants commonly used for the disinfection of laryngoscopes are evaluated. We formed 14 groups consisting of 10 blades in each. The first 7 groups were contaminated with hospital related meticillin resistant Staphylococcus aureus (MRSA), and the other 7 groups with hospital related multiple resistant Pseudomonas aeruginosa (PA). For the first group of blades, no disinfection procedure was carried out and, were assumed as a control group. Blades in other groups were rested for 10 minutes in containers containing 70 % alcohol, 1/100 dilution of cetrimide, 1/100 dilution of chlorhexidine, 1/10 dilution of chlorhexidine, 1/10 dilution of povidone iodine, and 1/100 dilution of ammonium chloride in groups II,III,IV,V,VI, and VII respectively. Disinfectant used in a group was considered as effective when growth was seen in 5 or less than 5 plates representing that group. All disinfectants tested were found effective on decontamination of laryngoscopes. 5 different moderate level disinfectants which are commonly used for the disinfection of laryngoscopes have been found effective even on resistant hospital microorganisms like MRSA and P. aeruginosa. Finding effective, cheap and time saving methods by choosing a specific disinfectant, concentration and contact time is not difficult as long as clinicians are aware of the principles of the laringoscopes disinfection procedures.
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    Second-line drug susceptibilities of multidrug-resistant Mycobacterium tuberculosis isolates in Aegean Region - Turkey
    (2008) Özkütük N.; Sürücüoǧlu S.; Gazi H.; Coşkun M.; Özkütük A.; Özbakkaloǧlu B.
    Aim: The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing, and the standard shortcourse regimen used for the treatment of TB is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing is necessary to select an appropriate treatment regimen. Unfortunately, there are few studies showing the pattern of the second-line drug resistance in Turkey. We aimed to analyze the resistance to second-line anti-tuberculosis drugs of MDR strains of Mycobacterium tuberculosis isolated from the Aegean region of Turkey. Materials and Methods: In this study, drug susceptibility testing of 40 MDR-TB strains isolated from the Aegean region of Turkey was performed using the BACTEC 460 TB radiometric system. Capreomycin, ethionamide, kanamycin, amikacin, clofazimine and ofloxacin were tested in 1.25 μg/ml, 1.25 μg/ml, 5.0 μg/ml, 1.0 μg/ml, 0.5 μg/ml, and 2.0 μg/ml concentrations, respectively. Results: The results showed that 37.5% of the strains were resistant to ethionamide, 25% to capreomycin, 5% to kanamycin, amikacin and ofloxacin, and 2.5% to clofazimine. One (2.5%) of the 40 MDR-TB cases was defined as extensively drug-resistant tuberculosis (XDR-TB). Conclusions: The results of the study indicate that the high rates of resistance to ethionamide and capreomycin may be a problem in the treatment of patients with MDR-TB; XDR-TB is not yet a serious problem in our region. © TÜBİTAK.
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    Distribution of hepatitis C virus genotypes in Manlsa region, Turkey; [Manisa bölgesinde hepatit C virus genotiplerinin daǧilimi]
    (2009) Şanlidaǧ T.; Akçali S.; Özbakkaloǧlu B.; Ertekin D.; Akduman E.
    The duration of hepatitis C virus (HCV) infection and the response to the standard therapy is strongly related to the HCV genotypes. In addition, the geographical distribution of HCV genotypes is important for the epidemiological studies in terms of distribution and possible risk groups. The aim of this retrospective study was to investigate the distribution of HCV genotypes in Manisa region (located at the Aegean part of Turkey). A total of 100 anti-HCV (microparticle EIA; Abbott Laboratories, USA) and HCV-RNA (real time RT-PCR; Applied Biosystems, USA) positive patients (53 female, 47 male; mean age: 44.4 ± 10.4 years), who were admitted to Celal Bayar University Medical School Hospital between 2002-2005, were included to the study. Quantitative HCV-RNA levels of the patients were between 10 4-10 8 copies/ml. Complementary DNAs obtained from HCV-RNAs isolated by Invitek RTP DNA/RNA Virus Mini Kit were used for genotyping with selected primers [primer 11 (5'-AGG TCT CTG AGA CCG TGC ACC ATG AGC AC-3') and primer 13 (5'-CTG TGA GGA ACT ACT GTC TT-3') for the first PCR; primer 12 (5'-ACT GCC TGA TAG GGT GCT TGC GAG TG-3') and primer 14 (5'-CAC GCA GAA AGC GTC TAG-3') for the second PCR]. The RT-PCR products were purified with Invisorb Spin PCRapid Kit and sequenced by BigDye Terminator v3.1 Cycle Sequencing Kit in ABI Prism 310 Genetic Analyzer. Genotype 1 was found in 92% of the patients (92%) and genotypes 2 and 4 were found in 7% of the patients, while HCV genotype could not be identified in one patient (1%). When evaluating the subtypes, genotype 1 b was determined in 90 patients (90%), genotype 4a in five patients (5%), genotype 1 a in two patients (2%) and genotype 2a in two patients (2%). In conclusion, 1 b was found to be the most common HCV genotype in Manisa region in concordance with the previous data obtained in Turkey, followed by genotype 4a, although a rare one. The data of this study is noteworthy especially for the arrangement of treatment and follow-up of HCV infected patients.
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    Roles of phospholipase, esterase and slime activities of Candida albicans strains in infection-colonisation differentiation; [Candida albicans suşlarının fosfolipaz, esteraz ve slime aktivitelerinin enfeksiyon-kolonizasyon ayrımındaki rolleri]
    (Turkiye Klinikleri, 2012) Pekintürk N.; Deǧerli K.; Özkütük N.; Ecemiş T.; Kurutepe S.; Özbakkaloǧlu B.
    Objective: This study investigated slime factor, phospholipase and esterase activities of C. albicans strains isolated as the infectious agent from healthy individuals, their effectiveness as virulen-ce factors and interactions between each other. For this purpose, virulence factors of 50 C.albicans stra-ins isolated from specimens as infectious agent (infection group) and 50 C.albicans isolates obtained from oral smears of the control group (control group) were analyzed and roles of virulence factors in differentiation of colonisation and infection were investigated. Material and Methods: C.albicans ATCC 10039 and 50 C.albicans strains isolated from clinical specimes of patients who were treated in various clinics of our hospital were used as reference strains. The strains isolated from sterile body sites and from clinical specimens containing pseuduhyphe on direct examination were considered as infectious agent and were identified as C.albicans by germ tube test and chlamidospore formation. Yolc sac agar medi-um was used to detect phospholipase activity, Tween 80 agar medium was used to detect esterase acti-vity and Kongo red brain-heart infusion agar medium was used to detect slime activity. Results: There was no significant difference in terms of slime, phospholipase and esterase activities of C. albicans stra-ins isolated from patients compared to controls (p= 0.357, p= 0.842, p= 0.841). Consistency analysis be-tween virulence factors revealed no significant difference in the patient group. In the other hand, in the control group, esterase/phospholipase coexistence consistency was significant (K value= +0.35, p= 0.001). Conclusion: In conclusion, we suggest that many virulence factors of C. albicans have impor-tant roles in the development of C. albicans-related infections. © 2012 by Türkiye Klinikleri.