Browsing by Author "Türel Ermertcan A."
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Item A case of traumatic ulceration mimicking spinocellular carcinoma; [Spinosellüler karsinomu taklit eden skalp yerleşimli bir travmatik ülser](Turkiye Klinikleri, 2005) Şahin M.T.; Türel Ermertcan A.; Öztürkcan S.; Türkdoǧan P.In this article, it was aimed to show that ulcerations can develop not only following circulatory insufficiency, localized pressure, granulomatous degeneration, malignant tumors and local injections, but following exogenous traumas to skin as well. We present a 65-year-old male with a history of ulcer development on his nape following a cranial trauma 6 weeks before. A biopsy was taken to differentiate it from squamous cell carcinoma. Histopathologic examination revealed no tumor cell areas. Bacteriologic culture from ulcer floor revealed enterobacter. By enacting a combined systemic therapy with ciprofloxacin and gentamycin in addition to topical antiseptic therapy, the ulcer underwent complete remission in 15 days. This case is presented not only to draw attention to the possible clinical similarities between traumatic ulceration and squamous cell carcinoma, but also to emphasize the importance of differential diagnosis in the proper treatment of ulcers. Copyright © 2005 by Türkiye Klinikleri.Item Sexual dysfunction in patients with psoriasis(2006) Türel Ermertcan A.; Temeltaş G.; Deveci A.; Dinç G.; Güler H.B.; Öztürkcan S.Psoriasis can have a significant impact upon sexual function. The aim of this study was to investigate sexual function in females and males with psoriasis and to evaluate whether coexistent depression has an additional negative effect on sexual function in these patients. A total of 66 female subjects (39 with psoriasis and 27 healthy volunteers as a control group) and 70 male subjects (39 with psoriasis and 31 healthy volunteers as a control group) were enrolled in the study. A Psoriasis Area and Severity Index (PASI) was used to determine the severity of psoriasis for the patient groups. The Female Sexual Function Index (FSFI) was used to assess female sexual function and the International Index of Erectile Function (IIEF) was used to evaluate male sexual function. Quality of life was assessed with the Dermatology Life Quality Index (DLQI). The diagnosis of depression was made according to the Structured Clinical Interview for DSM-IV (SCID-I) interview and Hamilton Depression Rate Scale (HDRS) was used for grading depression. FSFI total score was found to be significantly decreased in female psoriatic patients without depression and psoriatic patients plus depression compared with healthy controls (24.09 ± 5.33 vs. 24.25 ± 4.52 vs. 28.12 ± 3.48, respectively, p = 0.004). However, FSFI score was not significantly different between patients with psoriasis without depression and those with psoriasis plus depression (p > 0.05). IIEF total score was also found to be significantly decreased in male psoriasis without depression and psoriasis plus depression patients compared with healthy controls (54.21 ± 13.07 vs. 52.0 ± 14.73 vs. 61.69 ± 9.49, respectively, p = 0.023). The difference in IIEF scores between patients with psoriasis without depression and in those with psoriasis plus depression were not statistically significant (p > 0.05). The results of the study demonstrated that patients with psoriasis, especially females have distinct sexual dysfunction compared with healthy controls, and coexistent depression has no additional negative effect on sexual dysfunction in our patients. Patients with psoriasis should be evaluated in terms of sexual function in order to provide a better quality of life. © 2006 Japanese Dermatological Association.Item A non-erythematous and depressed panniculitic lesion in the gluteal region: Lupus profundus or subcutaneous dermatofibroma?(2006) Şahin M.T.; Türel Ermertcan A.; Öztürkcan S.; Demireli P.[No abstract available]Item Sexual dysfunction in patients with chronic hand eczema in the Turkish Population(Blackwell Publishing Ltd, 2007) Ergün M.; Türel Ermertcan A.; Öztürkcan S.; Temeltaş G.; Deveci A.; Dinç G.Introduction. Hand eczema can cause considerable psychosocial disorders, such as anxiety, depression, and difficulties at work, and it may also cause sexual dysfunction. Aim. The aim of this study was to investigate sexual function in patients with hand eczema and to find out whether concomitant depression has an additional negative effect on sexual function in these patients. Main Outcome Measures. Sexual functions were evaluated in hand eczema patients. Methods. Ninety-one female (43 patients vs. 48 controls) and 79 male (45 patients vs. 34 controls) subjects were enrolled in the study. Hand eczema severity index was used to determine severity of hand eczema. The Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF) were used to assess sexual function. Quality of life was assessed with the Dermatology Life Quality Index. Diagnosis of depression was made based on the Structured Clinical Interview for the DSM-IV, while the Hamilton Depression Rate Scale was used for grading depression. Results. Among 43 female subjects with hand eczema, 26 had depression (60.46%); of the 45 male patients, 11 had depression (24.44%). FSFI total score was found to be significantly decreased in female patients with both eczema and depression compared with controls (20.84 ± 9.19 vs. 24.04 ± 3.40, P < 0.05). FSFI total score was found to be significantly decreased in female patients with both eczema and depression compared with those without depression (20.84 ± 9.19 vs. 22.23 ± 5.82, P < 0.05). IIEF total score was also found to be significantly decreased in male patients with or without depression compared with controls (52.36 ± 14.83 vs. 59.88 ± 5.65 vs. 62.03 ± 11.04, P < 0.05). Conclusions. The results of the study demonstrated that patients with hand eczema had sexual dysfunction, and concomitant depression had an additional negative effect on sexual dysfunction. Patients with hand eczema should be evaluated with regard to sexual function and depression to provide a better quality of life. © 2007 International Society for Sexual Medicine.Item Psoriatic plaque erosion: A rare side effect of methotrexate(2009) Bilaç C.; Türel Ermertcan A.; Öztürkcan S.; Şahin M.; Öztürk F.; Bayraktar Bilaç D.; Işisaǧ A.[No abstract available]Item Case report of a late onset bowenoid papulosis progressing to squamous cell carcinoma: Letter to the editor(Turkiye Klinikleri, 2009) Aydin N.; Türel Ermertcan A.; Öztürkcan S.; Bilaç C.; Yoleri L.; Temiz P.[No abstract available]Item Risk factors for delaying treatment seeking in obsessive-compulsive disorder(2010) Demet M.M.; Deveci A.; Taşkin E.O.; Erbay Dündar P.; Türel Ermertcan A.; Mizrak Demet S.; Bayraktar D.; Öztürkcan S.Background: Despite the multiple alternatives of treatment, it is well known that patients with obsessive-compulsive disorder (OCD) delay seeking treatment. In this study, the aim was to determine the risk factors for delaying treatment seeking in OCD patients. Methods: The sample consisted of 132 OCD who completed the Yale-Brown Obsessive-Compulsive Scale, Yale-Brown Obsessive-Compulsive Scale Symptom Checklist, and Beck Depression Inventory. Results: In univariate analyses with risk evaluation, income level, being single or divorced, having a history of psychiatric treatment, poor insight for the symptoms, and obsessions of hoarding were the variables that were found to be significant. In the regression model, history of psychiatric treatment and duration of OCD were the 2 variables that remained statistically significant. Conclusion: This was the first study wherein the sample included patients who were recruited from a nonpsychiatric department: the dermatology clinic. Application to dermatology has not been determined as a risk factor for delaying treatment seeking in OCD patients. © 2010 Elsevier Inc. All rights reserved.Item Sexual dysfunction in dermatology: Review; [Dermatolojide cinsel fonksiyon bozukluklari](2010) Türel Ermertcan A.Scientific advances are shedding new light on the understanding and treatment of long-recognized conditions located at the interface of dermatology and psychiatry. The skin is one of the major avenues by which we perceive the world, and, in turn are perceived by it. When the skin itself is markedly affected by a primary dermatologic condition, psychological sequelae often follow, greatly impacting the patient's self-esteem, confidence, and overall quality of life. Skin diseases, especially chronic and pruritic ones, may cause a variety of psychological problems, including demoralization, poor self esteem, distress, social phobia, anxiety, depression, sleep disturbances and obsessive-compulsive disorder. Besides they can diminish the patients' quality of lives, they can affect also the quality of lives of relatives and partners of patients with the disease. It is important to be able to measure these effects for clinical, therapeutic and health service research. Sexual health is also perceived as an integral part of general health and sexual dysfunction in different diseases in dermatology arena became a new subject in recent years. Skin and mind are two major components of sexual act. Skin plays major role from sexual arousal to orgasmic phases of sexual activity. Diseases of skin can affect directly and indirectly of sexual disorders. In this report, male and female sexual functions and sexual dysfunction in skin diseases have been reviewed. Female sexual functioning scales, male sexual functioning scales, scales using for both females and males, sexual dysfunction in systemic diseases and skin diseases have been discussed respectively. Copyright © 2010 by Türkiye Klinikleri.Item Halo angioma: A new clinical and dermoscopical description(2011) Kocabaş E.; Gençoǧlan G.; Öztürk F.; Türel Ermertcan A.[No abstract available]Item Acanthosis nigricans form of epidermal nevus and review of the literature: Case report; [Epidermal nevusun akantozis nigrikans formu ve literatürün gözden geçirilmesi](2011) Türel Ermertcan A.; Gençoǧlan G.; Demirer O.; Öztürk F.; Temiz P.Dermatological examination of a 12 year old girl with the complaint of brownish-black spots and itching on left axilla for approximately one year revealed hyperpigmented papules and plaques on the left axillary region. On dermoscopic examination of the lesions network structure associated with typical epidermal pigmentation was seen. Histopathologic examination of biopsy specimen taken from the lesions showed superficial hyperkeratosis, papillomatosis and acanthosis in the epidermis, mild perivascular chronic inflammatory cell infiltration in the dermis. The case, resembling acanthosis nigricans, linear verrucous epidermal nevus and zosteriform lichen planus at first sight, was diagnosed as acanthosis nigricans form of epidermal nevus with clinical, dermoscopic and histopathologic findings. The patient was treated with topical retinoic acid and showed significant improvement in the follow ups. Herein, with respect of our interesting case due to the atypical clinical appearence and rarely definition in the literature, clinical features, differential diagnosis, dermoscopic and histopathological findings of acanthosis nigricans form of epidermal nevus will be discussed. Copyright © 2011 by Türkiye Klinikleri.Item Thermotherapy in dermatology(2012) Bayata S.; Türel Ermertcan A.Heat has been used as a medicinal and healing modality throughout human history. Today, thermotherapy is being studied in the treatment of many diseases. Although the exact anti-infective mechanism of thermotherapy is yet to be solved, this historically important healing method has shown significant results in the treatments of a variety of dermatological infectious diseases ranging from simple acne to bacterial, parasitic and viral infections, in modern medicine. Induction of cellular apoptosis in medium doses and necrosis in high doses has made thermotherapy an important modality in the treatment of malignant tumors. Especially in dermatology, significant results have been achieved in the treatment of Bowen's disease, melanoma and simple warts. Thermotherapy, which today has also shown advancements in cosmetology, can be delivered by liquid nitrogen in the form of hypothermia and a variety of ways ranging from hot water pads to ultrasound and even to lasers, in the form of hyperthermia. In this article, the place of this historically important treatment method in modern medicine, especially in dermatology, has been reviewed by an extensive search of the literature. © 2012 Informa Healthcare USA, Inc.Item Primary cutaneous CD30-positive anaplastic large cell lymphoma in a 16-year-old girl(2012) Kocabaş E.; Türel Ermertcan A.; Akinci S.; Temiz P.; Gündüz K.[No abstract available]Item Malignant acanthosis nigricans associated with ileocecal adenocarcinoma(2013) Gunduz K.; Coban M.; Öztürk F.; Türel Ermertcan A.Malignant acanthosis nigricans (MAN) is a cutaneous sign of internal malignancy, usually an adenocarcinoma. With this report, we aim to present a rare case of concomitant colon cancer and acanthosis nigricans (AN). A 62-year-old woman with hyperpigmentation, velvety cutaneous thickening and verrucous excrescences involving the axillary, inframammar, and inguinal regions with a history of 10 years is presented. Hyperpigmentation and thickening existed also on the nape, umbilicus, and periorbital regions. Histopathological findings of skin lesions were consistent with AN. Computed tomography of the abdomen revealed cecal wall thickening and multiple enlarged lymph nodes in pericolic fat tissue. The tumor was resected surgically and the diagnosis of poor differentiated adenocarcinoma of the colon with lymphatic metastasis was established. Although MAN is mostly reported in the course of abdominal malignancies, this is a very rare case report of MAN associated with adenocarcinoma of the colon. © 2013 Informa Healthcare USA, Inc.Item Coexistence of psoriasis and bullous pemphigoid: Remission with low-dose methotrexate(2013) Gunay U.; Gunduz K.; Türel Ermertcan A.; Kandiloǧlu A.Ri.The coexistence of psoriasis vulgaris and bullous pemphigoid is rare. Here, we report a 90-year-old patient with a 20-year history of psoriasis. She developed vesicles and bullae suddenly and was diagnosed as bullous pemphigoid. Low-dose methotrexate therapy quickly cleared both psoriatic and bullous lesions. © 2013 Informa Healthcare USA, Inc.Item Hyperbaric oxygen therapy for the management of chronic wounds(2013) Öztürk F.; Türel Ermertcan A.; Inanir I.Wound healing is actually a complex, precisely coordinated interaction between inflammatory cells and mediators, establishing significant overlap between the phases of wound healing. Chronic wounds are defined as wounds that do not follow the well-defined stepwise process of physiologic healing. The true incidence and economic impact of chronic wounds are difficult to assess because of the wide range of causative diseases and available treatment options. Despite multiple simultaneous and sequential therapeutic approaches, chronic wounds are highly resistant to treatment and are often indolent or even slowly progressive. Hyperbaric oxygen therapy (HBOT) has been explored as a treatment modality for chronic wounds because of its potential to promote healing and reduce bioburden in the wound bed. Multiple potential beneficial effects for wound healing have been demonstrated in various laboratory studies and experimental animal models. In this manuscript, HBOT, its mechanism of action, adverse effects and usage in diabetic and nondiabetic chronic wounds have been reviewed. © 2012 Informa Healthcare USA, Inc.Item A rare vasculitis type in a patient with acute myeloblastic leukemia: Annular leukocytoclastic vasculitis as a paraneoplastic syndrome?(Blackwell Publishing Inc., 2020) Çetinarslan T.; Türel Ermertcan A.; Aydoğdu İ.; Temiz P.[No abstract available]Item Mycosis fungoides mimicking pigmented purpuric dermatosis(Blackwell Publishing Inc., 2020) Gökyayla E.; Çetinarslan T.; Temiz P.; Türel Ermertcan A.[No abstract available]Item Evaluation of the effect of surgical treatment on quality of life with the Dermatology Life Quality Index in patients with facial nonmelanoma skin cancer(Blackwell Publishing Inc., 2020) Çetinarslan T.; Evrenos M.K.; Bilaç C.; Özyurt B.; Türel Ermertcan A.Skin cancers are the most common type of cancer. Nonmelanoma skin cancers (NMSCs) are more common than melanoma. Although the mortality rate is low, cancer word can be frightening for patients. Surgery is the main treatment. As skin cancers are most commonly located on the face, undesirable cosmetic results can occur as a result of treatments or due to primary disease. Therefore, the quality of life of patients could be affected. To determine the effect of surgical treatment on quality of life of the patients with facial NMSC using the Dermatology Life Quality Index (DLQI) at baseline and 3 months after surgery. We aimed to see if there was any improvement in quality of life scores after surgery, and to identify factors affecting quality of life. A total of 255 patients; 174 basal cell carcinoma (BCC) (68.2%) and 81 squamous cell carcinoma (SCC) (31.8%) were included in our study. All participants completed DLQI at baseline and 3 months after surgery. The mean total DLQI scores were 6.37 ± 6.28 in patients with BCC, and 6.35 ± 6.16 in patients with SCC. The mean total DLQI scores were 3.96 ± 5.14 in patients with BCC (P <.001), and 4.49 ± 5.24 in patients with SCC (P <.001) 3 months after surgery. In patients with primary skin cancer, all subscale scores and total DLQI scores were worse than the recurrent skin cancer group in both BCC and SCC at baseline. According to the treatment modalities, total DLQI scores and all subscales were worse in the graft group in BCC and SCC patients at baseline. Interestingly, the sex and the type of skin cancer did not affect quality of life, but tumor localization ([auricula OR: 6.45 [95% CI: 1.28-37.47] and eyelid OR:0.20 [95% CI: 0.04-0.96]) treatment procedure ([flap procedure OR: 7.90 [95% CI: 2.64-23.62] and graft procedure OR: 5.47 [95% CI: 1.60-18.71]) and, primary tumor OR:3.86 (95% CI: 1.01-14.78) were significant. The quality of life of skin cancer patients was affected by tumor localization, treatment procedure, primary, or recurrent tumor. The quality of life showed a significant improvement in patients with facial NMSC after surgical treatment. However, the type of NMSC seems to have no effect on the quality of life. © 2020 Wiley Periodicals LLC.Item The reliability of tuberculin skin test in the diagnosis of latent tuberculosis infection in psoriasis patients: A case-control study(Blackwell Publishing Inc., 2020) Sürücüoğlu S.; Türel Ermertcan A.; Çetinarslan T.; Özkütük N.Tuberculin skin test (TST), which is used in the diagnosis of latent tuberculosis infection, may cause Koebner's phenomenon and false-positive results in psoriasis patients. The purpose of this study is to compare TST with QuantiFERON-TB Gold Plus (QFT-plus) test in psoriasis patients and to determine the effects of psoriasis on TST results. Ninety-two psoriasis patients and 30 control subjects were included in the study. QFT-plus test, TST, and prick test to distinguish the increase of induration because of the skin trauma were performed on both groups. The demographics, risk factors for latent tuberculosis infection, BCG vaccination history, Koebner's history, psoriasis severity, and treatment history of the patients were recorded. The effects of these variables on test results were investigated by comparing those with control group. The criteria of National Tuberculosis Diagnosis and Treatment Guidelines were used in the evaluation of test results, and threshold value of positivity for TST was taken as 10 mm in BCG-vaccinated patients who are planned to start biological treatment. Prick test results were negative in the control group. There was no significant relation between the results of prick test and TST induration diameters in the patient group. Although TST positivity was significantly higher in patients (62%) compared with control group (33%), QFT-plus test results were not statistically different between two groups. Agreement between two tests was determined to be low in patient group with 48% (K = 0.1), and it was determined to be moderate with 77% in control group (K = 0.4). QFT-plus test was found to be negative in 46 of 57 TST-positive patients (80.7%) in patient group. It was determined in both groups that vaccination did not have any effect on test results. When threshold value was lowered to 5 mm in patient group without considering BCG reaction, the number of TST-positive patients increased from 57 to 65. Mean TST induration diameter was 10 mm and 14 mm in cases with mild and moderate to severe clinical manifestation, respectively (P =.04). However, no effect of disease period and treatment was determined on both test results. TST positivity was higher in psoriasis patients compared with control group. It was considered due to the increased reaction of the skin to mycobacterial antigens rather than the Koebner's response. Although TST results were not affected by BCG, it was concluded that a 10-mm threshold value of positivity was a suitable approach in order to reduce the number of patients receiving unnecessary preventive treatment in patients who are considered to initiate biologic agents. Furthermore, it was also concluded that QFT-plus test may be preferred in psoriasis patients since it is applied in vitro and its specificity is higher and not affected by disease severity. © 2020 Wiley Periodicals LLC.Item Functional medicine with dermatology insite: A systematic approach for diagnosis and treatment of chronic diseases(Blackwell Publishing Inc., 2020) Gökyayla E.; Türel Ermertcan A.; Bilaç C.[No abstract available]