Araştırma Çıktıları | Web Of Science

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    The antinociceptive effect of leukotriene D4 receptor antagonist, MK-571, in mice
    Gök, S; Önal, A; Çinar, MG; Evinç, A
    The effect of a leukotriene D-4 receptor antagonist, (3-(3-(2-(7-chloro-2-quinolinyl)ethenyl) amino-3-oxo plopyl)thio)methyl)thio) propanoic acid (L-660,711; MK-571), was investigated on nociceptive responses in mice using three different assays: acetic-acid-induced abdominal constrictions, formalin response and tail-flick test. MK-571 (8-32 mg/kg, i.v.) produced dose-dependent protection against acetic-acid-induced abdominal constriction (ED50 = 30 mg/kg). The compound (10-80 mg/kg, i.p.) was also effective, in a dose-dependent manner, on the second phase of the formalin response (ED50 = 26 mg/kg). However, it had no effect on the first phase of the formalin response and in the tail-flick test. Naloxone (1 mg/kg, i.v.), an opioid antagonist, almost completely blocked the antinociceptive effect of MK-571 in both acetic-acid-induced abdominal constriction and the second phase of the formalin test. These results provide evidence for an antinociceptive action of MK-571 at peripheral sites and suggest that opioid mechanisms are involved. (C) 1999 Elsevier Science B.V. All rights reserved.
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    Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey
    Ozbilgin, A; Durmuskahya, C; Kayalar, H; Ostan, I
    Resistant infections lead to increased necessity of searching novel drugs and drug combinations. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in Turkey for antipyretic and analgesic purposes. Lavandula stoecheas subsp. cariensis, Phlomis nissolii, Phlomis bourgaei, Phlomis leucophracta, Centaurea hierapolitana, Centaurea polyclada, Centaurea lydia, Scrophularia cryptophila, Scrophularia depauperata, Scrophularia floribunda, Rubia davisiana, and Alkanna tinctoria subsp. subleiocarpa were investigated for their in vivo antimalarial activities in mice infected with Plasmodium yoelii. Two hundred fifty to 500 mg/kg doses of plant extracts were given to mice as a single daily dose for 4 days. P. nissolii water extract, C. lydia chloroform extract, S. cryptophila ethanol extract, and C. polyclada methanol extract showed antimalarial activity with reducing parasitaemia. The chemotherapeutic effects of plant extracts ranged between 13.5 % and 66.91 %. The chemosuppressions exerted by combined plant extracts of P. nissolii, S. cryptophila, and C. lydia with C. polyclada methanol extract were detected as 51.25 %, 57.33 %, and 58.33 %, respectively. Investigation of cytotoxic activities against brine shrimps revealed that methanol extract of C. polycada, chloroform extract of C. lydia, and ethanol extract of S. cryptophila showed cytotoxic activities, while water extract of P. nissolii was not active against brine shrimps.
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    Development of welded overlap core steel encased buckling-restrained braces
    Bozkurt, MB; Topkaya, C
    This paper reports development of a new type of buckling-restrained brace (BRB) named the welded overlap core steel encased BRB. A two phase experimental research program was undertaken where BRBs were investigated under subassemblage testing. The first phase of the program aimed at studying the performance of steel encased BRBs which utilize constant width core plates. Test results indicated that these braces develop unacceptably high compression and tension resistances and the behaviors of these BRBs under uniaxial testing and subassemblage testing are markedly different. In the second phase of the research program a new type of BRB which utilizes a welded overlap core was developed to improve the cyclic performance observed in the first phase. Experimental results showed that the braces sustain axial strains that vary between 2.0 and 2.5% and resistances in tension and compression were found to improve significantly when compared with the findings of the first phase. Welded overlap core steel encased BRBs were found to sustain cumulative axial strains that are 419 times the yield strain when properly detailed. (C) 2016 Elsevier Ltd. All rights reserved.
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    Factors affecting quality of life of caregivers of children diagnosed with autism spectrum disorder
    Özgür, BG; Aksu, H; Eser, E
    Context: Since autism spectrum disorder (ASD) is a lifelong disease and because of its nature, the negative effects of the disease on the quality of life (QoL) of caregivers as well as patients are incontrovertible. Aims: It was aimed to evaluate the effect of the variables related to both parents and children on the QoL scores of the parents of the children with ASD. Settings and Design: This is a causality analysis study. Subjects and Methods: Questionnaire on sociodemographic/disease-related variables, QoL in Autism Questionnaire-Parent Version (QoLA-P), autism behavior checklist and Clinical Global Impression scale were assessed of 162 patients with ASD. Statistical Analysis Used: Unpaired t-test, Mann-Whitney U test, Kruskal-Wallis test, and one-way ANOVA test were used for comparing groups. The parameters found to be statistically significant for QoLA-P in different analyses were included as the independent variable in the logistic regression analysis. The backward (variable elimination) model was selected as the model in the analysis. Results: The causality has been established may be stated as the severity of autism, the presence of psychiatric disorder in the mother/father. attendance of the child at school, duration since the diagnosis of autism, and the child's medication use. Conclusions: Autism affects the QoL of caregivers. The intervention of treatment by considering the factors that affect the QoL positively or negatively may increase the QoL of caregivers.
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    The effects of nursing interventions on the level of anxiety and care burden of the caregivers of bedridden patients
    Bayrak, B; Ozkan, CG; Demirbag, BC
    Background: Taking care of bedridden patients at home is a very difficult task for caregivers. In this care process, caregivers can be supported with the interventions given by the nurses at home. Aim: This study mainly aimed to compare the anxiety and care burden levels of caregivers of bedridden patients at home after nursing interventions which a personal care handbook, regular home visits, and telephone counseling. Subject and Methods: To proceed with this study, 51 caregivers have included in this study between January 1 and July 21, 2018. The Barthel Index for Activities of Daily Living (BIADL) was used to measure levels of independence in patient's activities, State and Trait Anxiety Scale (SAI and TAI) was used to measure the anxiety levels, and Burden Interview (BI) care burden problems of caregivers who participated in the study. Also, Sociodemographic Characteristics Form was used for demographic data of patients and caregivers. Results: The analysis of the responses showed the proportions of the caregivers who had lower SAI- TAI and BI scores after taking nursing intervention at home. The state anxiety level of caregivers (pre-test: Mean; 54.06+-7.97; post-test: Mean; 38.43+-6.41) and the trait anxiety level of the caregivers (pre-test: Mean; 51.45+-5.94; post-test: Mean; 41.59+-7.05) and the burden level of caregivers (pre-test: Mean; 75.75+-11.41; post-test: Mean; 57.69+-13.39) was determined. The differences between the pre and post-test mean scores of SAI, TAI, and BI were statistically significant (P < 0.05). Conclusions: Our study highlights that the burden and anxiety levels of the caregivers had lower post-test levels than the pre-test levels.
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    Optimization of HIL-HTL-free naphthalimide: Isoquinoline TEOLEDs with BZO top electrode
    Varol, SF; Sayin, S; Merdan, Z
    The present work focuses mainly on HIL/HTL-free TEOLEDs with furan-appended naphthalimide: isoquinoline (furan IQ) and morpholine-appended naphthalimide: isoquinoline (morpholine IQ), which were synthesized from the reaction between naphthalic anhydride and a substituent such as 2-furoic hydrazide or 4-aminomorpholine. Both of the emitters displayed aggregation-induced emission enhancement (AIEE) behavior. This new structure was constructed between modified indium tin oxide (ITO) with caesium fluoride (CsF) (5.18 eV) and boron-doped zinc oxide (BZO) (3.20 eV) with ideal work functions. The current densities were 400 mA.cm(-2) and 387 mA.cm(-2) and luminances were in the range of 9500 cd.m(-2) 9000 cd.m(-2) for the furan IQ and morpholine IQ emitters, respectively. We have introduced a new CsF-ITO/EML/LiF/BZO design with external quantum efficiencies (EQEs) of 9.50 % and 7.57%. We have achieved a standard deep violet/blue CIE coordinates of (0.15, 0.06) and (0.16, 0.05) for furan IQ and morpholine IQ emitters with a high color stability.
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    Genotoxic effects of industrial wastewater on Allium cepa L.
    Sik, L; Acar, O; Aki, C
    The aim of this research is to study the effects of different concentrations of water on both incoming and outgoing in central biological and chemical wastewater treatment plant in Manisa (Turkey) organized industrial zone (MOIZ) on the Allium cepa L. root meristems, having been rooted in distilled water for 48 h. The union bulbs were kept in the 100% concentrations of the refined water (RW) and of 10, 25, 50 and 100% concentrations of unrefined water (UW). Distilled water was used for the control samples. It was determined that wastewater reduced the rate of the mitotic division of different concentrations and increased the mitotic anomalies. Mitotic index was found to be 33.8, 31.2, 23.6 and 16.7% in the control group, RW, 10% concentration of the UW, and 25% concentration of the UW, respectively. On the other hand, the rates of Mitosis / (Anaphase + Telophase) were 0.23, 0.28, 0.42, 0.71 in the control group, RW, % concentration of the UW, and 25% concentration of the UW, respectively. Plant growth was interrupted in the 50 and 100% concentrations of the UW and the mitotic division was inhibited. No anomalies were encountered in the control group. In the RW, a low rate of anomaly was observed, while in the different concentrations of the UW, chromosomal aberrations such as high frequency of lagging chromosome, irregular distribution, polar slips, horizontal division and sticky chromosome were observed.
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    The effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients
    Gonul, AS; Akdeniz, F; Taneli, F; Donat, O; Eker, C; Vahip, S
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    Polyphenoloxidase deactivation kinetics during ohmic heating of grape juice
    Içier, F; Yildiz, H; Baysal, T
    The heating method affects the temperature distribution inside a food, and directly modifies the time-temperature relationship for enzyme deactivation. Fresh grape juice was ohmically heated at different voltage gradients (20, 30, and 40 V/cm) from 20 degrees C to temperatures of 60, 70, 80 or 90 degrees C and the change in the activity of polyphenoloxidase enzyme (PPO) was measured. The critical deactivation temperatures were found to be 60 degrees C or lower for 40 V/cm, and 70 degrees C for 20 and 30 V/cm. Various kinetic models for the deactivation of PPO by ohmic heating at 30 V/cm were fitted to the experimental data. The simplest kinetic model involving one step first-order deactivation was better than more complex models. The activation energy of the PPO deactivation for the temperature range of 70-90 degrees C was found to be 83.5 kJ/mol. (c) 2007 Elsevier Ltd. All rights reserved.
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    Experimental and numerical investigation of impact behavior of RC slab with different opening size and layout
    Yilmaz, T; Anil, Ö; Erdem, RT
    The present study intends to investigate the dynamic responses and failure modes of two-way reinforced concrete (RC) slabs that have openings in different sizes and locations under the impact load effect. RC slabs may include the openings due to the various architectural imperatives. Stair and elevator openings, ventilation openings, the openings left for the electricity, and the water installations can be given as examples of openings taken place in the RC slabs. Many studies related to RC slabs subjected to the static and the reversed-cyclic dynamic loads have existed in the literature. However, at the end of the detailed literature review conducted, the authors have not encountered a comprehensive study focused on the RC slabs' impact behavior that has openings in different sizes and locations. In the present experimental study's scope, the impact loading was applied to two-way RC slabs with the openings via the drop-weight test setup designed by the authors. The time-histories of acceleration and displacements measured from the RC slabs and impact forces acting on the RC slabs have been recorded during the tests to investigate the effect of opening sizes and locations on the RC slabs' impact performance. Furthermore, a finite element model (FEM) has been developed using ABAQUS software to calculate dynamic response and failure modes of the RC slabs with openings. Good agreement between experimental and numerical results has proven that the proposed FEM could be used to evaluate the impact behavior of the RC slabs that have the openings.
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    Changes in chemical, textural and sensory characteristics of Crottin de Chavignol cheese manufactured from frozen curd and packaged under modified atmosphere
    Esmer, O; Balkir, P; Seckin, AK
    Crottin de Chavignol is one of the most important cheeses produced from pasteurized goat milk. In this research, the effect of vacuum and modified atmosphere packaging techniques on the Crottin de Chavignol cheese, manufactured from frozen and thawed curd, was investigated. The frozen curd stored for 6 months at -25 degrees C and then thawed and processed into cheese by following the same procedure as for the fresh curd. The cheese was packaged under modified atmosphere (MAP) of 20 % CO2 + 80 % N-2 and vacuum. The control cheese samples were packaged under ambient atmosphere. Cheeses were sampled for physicochemical, textural and sensory analyses on day 0 and after 3, 6 and 9 weeks. The cheese group packaged under ambient atmosphere could not be evaluated organoleptically after 6(th) week because of mould and yeast growth. The effect of packaging technique on color (L-star, a(star) and b(star) values), on some textural parameters (hardness, gumminess and chewiness) and flavor scores was found significant. However, no significant difference was found between MAP and vacuum packaged cheese groups except for some textural characteristics as hardness, gumminess and chewiness.
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    Bone Marrow Radiation Dose in Thyroid Carcinoma Patients Treated with Iodine-131
    Parlak, Y; Demir, M; Erees, S; Gumuser, G; Uysal, B; Kaya, GC; Koc, M; Ergene, U; Sayit, E
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    Fruit Juice Quality Enhancement by High-Pressure Technology
    Tokusoglu, Ö; Swanson, BG; Barbosa-Cánovas, GV
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    Two-to-one internal resonances in continuous systems with arbitrary quadratic nonlinearities
    Pakdemirli, M; Özkaya, E
    Vibrations of a general continuous system with arbitrary quadratic nonlinearities are considered. The nonlinearities are expressed in terms of arbitrary quadratic operators. The two-to-one internal resonance case is considered. A general approximate solution is presented for the system. Amplitude and phase modulation equations are derived. Steady state solutions and their stability are discussed in the general sense. The sufficiency condition for such resonances to occur is derived. Finally the algorithm is applied to a specific problem.
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    Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells
    Sezer, T; Altinisik, M; Guler, EM; Kocyigit, A; Ozdemir, H; Koytak, A
    Objective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times. Material and methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Cells in the control group were not exposed. RPE cell cultures were compared in terms of cell viability, DNA damage, apoptosis rate, and IL-1 ss, IL-6, and TNF- alpha levels. Results: The halogen light group showed significantly more DNA damage, higher TNF-alpha, IL-1 beta, and IL-6 levels, and lower viable cell count at 30 min compared to the control group. The rates of early and late apoptosis were also significantly higher at 60 min. There were no statistically significant differences in any of the parameters between the xenon and LED light sources and the control group at 30 or 60 min. Conclusion: New generation lights, xenon, and LED, seem to be safe in terms of RPE cells. Halogen light may cause toxic effects on RPE cells when used for a long time with maximal power output.
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    Histopathological and Genotoxic Effects of Pollution on Anguilla anguilla in the Gediz River (Turkey)
    Yildiz, S; Gurcu, B; Koca, YB; Koca, S
    The aim of the present study was to determine heavy metal accumulation in water, sediment and some tissues of Anguilla anguilla along with determining histopathological and genotoxic effects of accumulation on these tissues by using light microscopy. Water, sediment and fish tissue samples taken from different sites of 3 different study areas were studied and the order of accumulation of metals was Fe>Pb>Mn>Co>Zn>Ni> Cr>Cu>Cd in water, Fe>Co>Mn>lpb>Zn>Ni>Cr>Cu>Cd in sediment and Cd>Mn>Cu>Cr>Ni>Fe>Zn>Co>lpb, Cd>lpb>Ni>Cr>Mn>Cu>Fe>Co>Zn and Cr>Ni>Zn>Cd>lpb>Mn>Cu>Fe>Co in liver, muscle and gill of fish, respectively. In histopathological studies, a decrease in the length of primary and secondary lamellae of gills, fusion in secondary lamellae, cellular proliferation, clavate lamellae formation and necrosis were observed. In liver tissue, dilation of sinusoid, increase in the number of erythrocytes, ruptured hepatocytes, decrease in glycogen accumulation and vacuolization were observed. In muscle tissue, necrosis, cellular dissolution and loss of striatation in muscle fibers were found. It was observed that pollution of water had no genotoxic effect on Anguilla anguilla.
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    Analytical solution of laser short-pulse heating of gold films
    Yilbas, BS; Pakdemirli, M
    Laser short-pulse heating of metallic surfaces results in the thermal separation of electron and lattice sub-systems. In this case, the electron temperature well in excess of the lattice site temperature results. The process is concerned in the thermal coupling of two sub-systems and the resultant energy transport equation becomes hyperbolic for the timescales of time and space considered. In the present study, analytical solutions for electron and lattice site temperatures are obtained using a perturbation method. In the analysis, a gold film is used and the laser pulse intensity is varied exponentially. The absorption mechanism is assumed to follow an exponential decay within the absorption depth of the substrate material. It is found, that temporal behaviour of the electron temperature is similar to that corresponding to the laser pulse intensity, provided that both curves have different temporal gradients. The electron temperature decays wheas the lattice site temperature increases continuously with time.
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    Carbonic Anhydrase Activity as a New Parameter in Exercise Physiology
    Tas, M; Sentürk, E; Sentürk, M; Çomakli, V; Demirdag, R; Bayram, M; Akyüz, M; Göktepe, M