Araştırma Çıktıları | Web Of Science

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The acute effect of orlistat on endothelial function in young obese women
Sekuri, C; Tavli, T; Avsar, A; Sozcuer, H; Uyanik, BS; Ari, Z
Recent studies indicate that abdominal fat accumulation is related to impaired endothelial function in young healthy volunteers. The aim of this study was to determine the acute effect of gastrointestinal lipase inhibitor on brachial flow-mediated vasodilatation and hemodynamic parameters in young obese women. The study population was composed of 42 female obese patients (mean age 29 +/- 4 years, age range between 18 and 34 years). Flow-mediated endothelial-dependent vasodilatation was assessed in the brachial artery in response to reactive hyperemia using high-resolution ultrasound. Brachial artery diameter (3.46 +/- 0.72 mm to 3.82 +/- 0.84 mm) and flow-mediated vasodilation (7.6 +/- 0.8% to 9.8 +/- 1.6%) changed significantly after 12 weeks of therapy (p < 0.001). Brachial artery flow was not changed (124 +/- 92 ml/min to 148 +/- 14 ml/min, p > 0.05). The results of this study demonstrate that orlistat improved endothelial function, weight, body mass index and systolic and diastolic blood pressure in young women.
Increasing production rate in U-type assembly lines with sequence-dependent set-up times
Sahin, M; Kellegöz, T
U-shaped assembly lines are commonly used in just-in-time production systems as they have some advantages over straight lines. Although maximizing production rates on these lines by assigning tasks to stations is common practice in industrial environments, studies on the stated assembly line balancing problem are limited. This article deals with maximizing the production rate on U-shaped assembly lines under sequence-dependent set-up times. Sequence-dependent set-up times mean that after a task is performed, a set-up time, the duration of which depends on adjacent tasks, is required to start the next task operation. These set-ups are considered by dividing them into two groups, named forward and backward set-ups, to make the problem more practical. Two heuristics based on simulated annealing and genetic algorithms are improved beside the mathematical model. Experimental results show that solving the stated problem using the mathematical model is nearly impossible, while heuristics may obtain solutions that have acceptable deviations from the lower bounds.
Mechanical and fluoride release properties of titanium tetrafluoride-added glass-ionomer cement
Pamir, T; Sen, BH; Celik, A
The aim of this study was to determine the fluoride-release and mechanical properties of a water-hardening glass-ionomer cement (GIC) (ChemFil Superior) when titanium tetrafluoride (TiF4) was added. Three experimental groups were prepared with TiF4 added to the liquid component of the material in concentrations of 0.5, 1, and 2%. The control group was the original form of the cement and free of TiF4. After the specimens (4 nun in diameter X 6 mm in length) were prepared, their compressive strength, microhardness, modulus of elasticity, and fluoride release were measured. Data were analyzed using one-way analysis of variance (ANOVA) and post-hoc test (Bonferroni/Dunn correction). The addition of TiF4 into GIC significantly reduced fluoride release from the material with the exception of 1% TiF4 (p < 0.0083). Compressive strengths of 0.5 and 1% TiF4-added GICs were higher than that of the original GIC, but it was not statistically significant (p > 0.05). The differences among modulus of elasticity values of experimental and control groups were not significant (p > 0.05). Similarly, microhardness of GIC was not affected with TiF4 addition (p > 0.05).
A Comparison of Smokers, Non-Smokers, and Those Undergoing Treatment in Terms of Attitudes on Coping with Stress and Psychological Resilience
Acar, S; Kayli, DS; Yararbas, G
This study compares the attitudes on resilience and coping with stress of smokers, non-smokers, and those undergoing smoking-cessation treatment. This study involves three study groups: 116 people who applied to the Institute on Drug Abuse, Toxicology, and Pharmaceutical Science Smoking Cessation Polyclinic in Ege university to stop smoking, 110 smokers, and 121 non-smokers. The individual information form has been prepared in order to measure the variables of gender, age, and education level. In addition to the individual information form, the Fagerstrom Test for Nicotine Dependence, the Brief Coping Styles Inventory (Brief COPE), and the Resilience Scale for Adults have been used. The Kruskal-Wallis and Mann-Whimey U tests have been utilized in addition to descriptive statistics in analyzing the obtained data. Based on multiple comparisons among the three groups, significant differences among the groups have been obtained in certain sub-dimensions for the variables in coping strategies and resilience, as well as significant differences between smokers and the other groups in terms of their levels of resilience.
Long term efficacy of fixed-dose omalizumab for patients with severe chronic urticaria
Havlucu, Y; Yorgancioglu, A; Havlucu, DY; Madak, B; Kurhan, F
The validity and reliability of the Turkish version of the Leicester Cough Questionnaire in COPD patients
Kurhan, F; Göktalay, T; Havlucu, Y; Sari, S; Yorgancioglu, A; Çelik, P; Coskun, AS
Background/aim: The reliability and validity of the Turkish version of the Leicester Cough Questionnaire (LCQ) have been evaluated before. This study aimed to validate the Turkish version of the LCQ in chronic obstructive puhnonary disease (COPD) patients with cough. Materials and methods: COPD (GOLD B, C, D) patients over age 40 (n = 75) and healthy volunteers as a control group (n = 75) were included. A sociodeinographic data form, the LCQ, the Short Form-36 (SF-36) quality of life questionnaire, and the World Health Organization Quality of Life Brief Form for Turkish people were completed. The internal reliability of the LCQ was determined using the Cronbach alpha coefficient (>0.6) and its repeatability by the intraclass consistency coefficient (P < 0.05) was accepted as significant. Results: For internal consistency, Cronbach alpha coefficients of all subscales of the LCQ, physical, psychological, and social, were found as 0.72, 0.86, and 0.83, respectively, with 0.92 for the total index. There was significant internal consistency for all subscales and the total index (Cronbach alpha coefficients of >0.6). In test-retest reliability, the correlation coefficient ranged between 0.71 and 0.80 for each question and was calculated as r = 0.89 for total LCQ score (P < 0.001). Conclusion: The Turkish version of the LCQ has been found to have acceptable reliability and validity for use in Turkish COPD patients with chronic cough.
DESCRIPTION OF THE UNKNOWN FEMALE OF THE HARVESTMAN RAFALSKIA AZIZSANCARI KURT, YAGMUR & TEZCAN, 2019 (ARACHNIDA: OPILIONES: PHALANGIIDAE) FROM TURKEY
Kurt, K; Yagmur, EA; Kurt, P
The female of Rafalskia azizsancari Kurt, Yagmur & Tezcan, 2019, previously known only from the male in Turkey, is now described based on new material from Odemis District, Izmir Province, Turkey. Detailed morphological descriptions, photographs and illustration of the female ovipositor are provided.
Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity
Özel, HE; Özdogan, F; Gürgen, SG; Esen, E; Genç, S; Selçuk, A
Objective: This study aimed to compare the efficacies of intratympanic dexamethasone and methylprednisolone in preventing in cisplatin-induced ototoxicity in rats. Methods: Experimental groups of rats (n = 8 each) received intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic isotonic saline, intraperitoneal cisplatin and intratympanic dexamethasone, or intraperitoneal cisplatin and intratympanic methylprednisolone. Distortion product otoacoustic emission thresholds were compared on days 0 and 10 in all rats, and correlations between drug effects and changes in cochlear histology were evaluated. Results: Distortion product otoacoustic emission thresholds were comparable in groups III and IV (p > 0.05). Significant protection against cisplatin-induced ototoxicity was seen in groups III and IV compared with group II (p < 0.05). Dexamethasone and, to a lesser extent, methylprednisolone protected against cellular apoptosis in cisplatin-induced ototoxicity. Conclusion: Dexamethasone (and possibly methylprednisolone) may be clinically useful as an intratympanic chemopreventive agent to treat cisplatin ototoxicity. Future clinical studies should investigate the use of dexamethasone for this purpose in adult patients.
Synthesis and vibrational spectroscopic study of some metal(II) halide and tetracyanonickelate complexes of isonicotinic acid
Ataç, A; Bardak, F
The M(IN)(2)Ni(CN)(4) [where M: Cu, Mn, Zn, IN: Isonicotinic acid, abbreviated to M-Ni-IN] tetracyanonickelate and some metal halide complexes with the following stoichiometries: Cu(IN)X-2 (X:Br,I), Cd(IN)(2)X-2, (X:Cl,Br), and Zn(IN)(4)X-2 (X:Br,I) were synthesized for the first time. Their FT-IR spectra were reported in the 4000-400 cm(-1) region. Vibrational assignments were given for all the observed bands. The analysis of the vibrational spectra indicates that there are some structure-spectrum correlations. For a given series of isomorphous complexes, the sum of the difference between the values of the vibrational modes of uncoordinated isonicotinic acid that were coordinated to the metal ion isonicotinic acid was investigated and found to depend on the halogen for a given metal. The proposed structure of tetracyanonickelate complexes consists of polymeric layers of vertical bar M-Ni (CN)(4)vertical bar(infinity) with the isonicotinic acid molecules bound directly to the metal (M) atoms. Certain chemical formulae were determined using the elemental analysis results.
A Study on Motion of a Robot End-Effector Using the Curvature Theory of Dual Unit Hyperbolic Spherical Curves
Sahiner, B; Kazaz, M; Ugurlu, HH
In this paper we study the motion of a robot end-effector by using the curvature theory of a dual unit hyperbolic spherical curve which corresponds to a timelike ruled surface with timelike ruling generated by a line fixed in the end-effector. In this way, the linear and angular differential properties of the motion of a robot end-effector such as velocities and accelerations which are important information in robot trajectory planning are determined. Moreover, the motion of a robot end-effector which moves on the surface of a right circular hyperboloid of one sheet is examined as a practical example.
Periosteal adventitia is a valuable bone graft alternative (vol 36, pg 341, 2013)
Gemalmaz, HC; Bolukbasi, S; Esen, E; Erdogan, D; Gürgen, SG; Bardakci, Y
What are the best surgical techniques for caesarean sections? A contemporary review
Hasdemir, PS; Terzi, H; Guvenal, T
The aim of this study was to evaluate the reported techniques used in caesarean sections in order to form a general perspective of the procedural options for this frequently performed operation. The PubMed database and Cochrane Reviews were searched separately with the key words 'caesarean', 'abdominal entry', 'abdominal incision', 'uterine repair', 'peritoneal repair', 'closure of abdominal incision', 'suture materials', 'extraction of the placenta' and 'review'. Reviews, meta-analyses and prospective randomised trials were included in this review. In conclusion, although caesarean delivery is a very common operation, standardised and globally accepted techniques for caesarean section have not been described. The best surgical techniques for this operation are still unknown. Although the long-term follow-up results from two large, prospective, randomised studies are pending, further research is needed to establish an evidence-based, standardised approach for caesarean sections.
A Novel Mathematical Model with Fairness Constraints for Uninterrupted Network Coverage in Disasters
Akpunar, ÖS; Akpinar, S
Drones can be used as base stations to support search and rescue operations due to damage to telecommunications infrastructure after a disaster. This involves identifying a number of hotspots over the disaster area where the drones should hover for a certain amount of time, and moving the drones between these points along the pre-determined routes. Allocating the drones to appropriate locations and finding optimal routes is an optimization problem, and solving this problem to optimality is crucial to ensure sustainable operations with limited resources. This paper addresses this optimization problem and presents the drone base station allocation and routing problem (DBSARP) under disaster conditions. The problem aims at separately optimizing two objectives: spatial coverage by maximizing the coverage areas and temporal coverage by maximizing the total hover time as well as considering fairness. A mathematical model is proposed to determine the locations and routes of the drone base stations (DBSs) and their lengths of stay at each location. Furthermore, a real-life implementation of the proposed model is realized based on the earthquake that happened in the Bayrakli district of Izmir, T & uuml;rkiye in 2020. Finally, a set of sensitivity analyses is performed by varying key parameters of the problem, such as battery capacities and number of the DBSs.
Some characterizations of Mannheim partner curves in the Minkowski 3-space E13
Kahraman, T; Önder, M; Kazaz, M; Ugurlu, HH
In this paper, we give some characterizations of Mannheim partner curves in the Minkowski 3-space E-1(3). Firstly, we classify these curves in E-1(3). Next, we give some relationships characterizing these curves and we show that the Mannheim theorem is not valid for the Mannheim partner curves in E-1(3). Moreover, by considering the spherical indicatrix of the Frenet vectors of those curves, we obtain some new relationships between the curvatures and torsions of the Mannheim partner curves in E-1(3).
Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis
Gok, S; Izanli-Paksoy, A; Vural, K
The exact mechanisms underlying the weak bronchodilator effect of K(ATP) channel openers on cholinergic stimulations is unknown. The present study was designed to examine the relaxant efect of pinacidil in guinea-pig trachea stimulated with carbachol by the presence of calcium sensitizer inhibitors; HA 1077, a rhoA kinase inhibitor, and chelerythrine, a protein kinase C inhibitor. Adenosine (10 mu M) was used as other contractile agent for comparison. Tracheal tissues were isolated from ovalbumin sensitized guineapigs and changes in tension were recorded isometrically. Pinacidil (1-100 mu M, cumulatively) and HA 1077 (0.01-30 mu M, cumulatively) produced concentration-dependent relaxations in unstimulated tisues. The relaxant response to pinacidil decreased in carbachol contracted tissues, but increased in adenosine-stimulated tissues. Pretreatment of the tissues with HA 1077 (0.1 mu M) and chelerythrine (10 mu M) increased the pinacidil-induced relaxations by similar to%100 and %40, respectively. Glibenclamide, a KATP channel blocker, partially antagonized the pinacidil response in contracted tissues. Glibenclamide also inhibited the carbachol and adenosine induced contractions. These results suggest that diminish effect of pinacidil may have related to the enhanced calcium sensitization by cholinergic stimulation. Rho kinase inhibitors appear more effective than PKC inhibitors to achieve of this failure.
Different venous end-to-side microanastomotic techniques
Yoleri, L; Songür, E
End-to-side venous anastomosis is sometimes necessary when there is the lack of a suitable vein, when there is a size discrepancy in the veins to be repaired, or when the anastomosis of multiple veins is required. The effects of elliptical vs. slit venotomy on vessel patency have not been investigated in a flap model. A new, simple, reliable, and reproducible model is described in which the femoral vein of the groin flap is anastomosed to the side of the deep dorsal penile vein. Elliptical hole and slit venotomies were tested in 26 Sprague-Dawley rats, and the anastomoses were 100% patent. The type of venotomy was not found to affect patency. Either technique is equally valid in end-to-side venous anastomosis, and the model itself is convenient for training.
Amlodipine-induced generalized fixed drug eruption clinically mimicking mycosis fungoides
Cetinarslan, T; Ermertcan, AT; Temiz, P
Perceived barriers to diabetes management at home: a qualitative study
Açli, D; Bahar, Z
Background: Diabetes is a complex and progressive disease and its treatment requires self-management strategies specific for each patient. The aim of the study was to determine perceived barriers to diabetes management at home in type II diabetes patients. Materials and methods: Inclusion criteria of this phenom-enological study included living in Izmir and a diagnosis for the last 1 year; 15 patients with diabetes participated the study. A semi-structured interview form based on Health Belief Model created by researchers with experts opinion, was used at in-depth face-to-face interviews. Data were analyzed with content analysis. Ethical and hospital approval was obtained. Participation of individuals is based on volunteerism; written informed consent from patients who accepted the study. Results: Perceived barriers to fulfilling home care needs and sustaining behavior of diabetes management included six themes, i.e. insufficient knowledge of diabetes, inability to accept diabetes, non-adherence to diabetes and exercise, problems with health care services, fear and effects of the family and the society and relevant subthemes. Conclusion: These findings about the barriers of the patients should provide guidance for patient specific nursing interventions.
Effect of Cationic Polyelectrolyte on the Flow Behavior of Hydroxypropyl Methyl Cellulose/Polyacrylic Acid Interpolymer Complexes
Sakar-Deliormanli, A
Association of polyacrylic acids and nonionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials. These complexes are novel individual compounds and their properties are entirely different from the properties of their component polymers. In this study, the effects of a cationic polyelectrolyte (polyethylenimine, PEI) on the interpolymer complexation of hydroxypropyl methyl cellulose (HPMC) with polyarcylic acid (PAA) in aqueous media were studied. Results showed that at low pH, interpolymer complex (IPC) formation was observed between HPMC and PAA at a 3:0.5 polymer ratio. Under basic conditions, the viscosity of the IPC increased accompanied with the transition from coiled structure to an extended conformation of associates. Addition of PEI to the same system caused some structural changes in the polymer solution mixtures depending on the pH of the system. PEI worked as a destructive agent for the HPMC/PAA interpolymer complexes and associates. This behavior was attributed to the complex formation between PEI and HPMC via hydrogen bonding.
Comparison of methanolic extracts of Doronicum orientale and Echium angustifolium in terms of chemical composition and antioxidant activities
Arumugam, R; Sarikurkcu, C; Ozer, MS
Medicinal plants have been a priceless source of medication in nearly all cultures and societies worldwide due to the presence of phytochemicals and their wide range of therapeutic potentials including antioxidants. In this study, the methanolic leaf extracts of Doronicum orientale and Echium angustifolium were screened for antioxidant activity and quantitative phytochemical analysis using LC-ESI-MS/MS. The study revealed that the D. orientale exhibited significantly highest total phenolic content as well as highest antioxidant activity in all tests. The quantitative phytochemical analysis using chromatographic analysis revealed significantly high content of hesperidin, chlorogenic acid, hyperoside, protocatechuic acid, gallic acid and quercetin in D. orientale, while E. angustifolium had rosmarinic acid, 4-hydroxybenzoic acid, p-coumaric acid, caffeic acid, vanillic acid, pinoresinol, syringic acid and luteolin-7-glucoside in higher contents. The results showed that the methanol extract of D. orientale could be an alternative source of natural agents in the management of the oxidative stress.

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