Browsing by Subject "discriminant analysis"

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    Depression and anxiety in hypothyroidism
    (2003) Demet M.M.; Ozmen B.; Deveci A.; Boyvada S.; Adiguzel H.; Aydemir O.
    The aim of the study was to determine the prevalence and severity of depression and anxiety inpatients with hypothyroidism and to compare this with euthyroid patients. Thirty patients with hypothyroidism and 30 euthyroid controls attending the Endocrinology outpatient department of Celal Bayar University, Medical Faculty were included in the study. The hormonal screening was done by immunoassay and haemagglutination methods. Then, for psychiatric assessment, Hospital Anxiety and Depression Scale (HAD), Hamilton Depression Rating Scale (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A) were used. There was no difference between the two groups in terms of demographic features. Total scores obtained from the scales used in the study did not differ significantly (p > 0.05). The frequency of items of both HAM-D and HAM-A did not show any differences in the two groups. By Wilks' Lambda discriminant analysis, depressive mood (HAM-D#1) was found to be the discriminating feature between the hypothyroid group and the euthyroid group. Therefore, depression and anxiety were not outstanding features in hypothyroidism. However, depression was more significant in the hypothyroid than euthyroid group.
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    Discriminant validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis: A cohort study
    (Springer Verlag, 2015) Kilic E.; Kilic G.; Akgul O.; Ozgocmen S.
    The aim of this study was to assess discriminant validity of Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) and to compare with The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) as clinical tools for the measurement of disease activity in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS). Also, the cut-off values for ASDAS-CRP in nr-axSpA and AS is revisited. Patients with axSpA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and were assessed for disease activity, quality of life and functional measures. The discriminatory ability of ASDAS-CRP and ASDAS-ESR was assessed using standardized mean differences and receiver operating characteristic (ROC) curves analysis. Optimal cut-off values for disease activity scores were calculated. Two hundred and eighty-seven patients with axSpA (nr-axSpA:132, AS:155) were included in this study. Two ASDAS versions and BASDAI had good correlations with patient’s and physician’s global assessment in both groups. Discriminatory ability of ASDAS-CRP, ASDAS-ESR and BASDAI were similar in patients with nr-axSpA and AS when the patients were assigned into low and high disease activity according to the ASAS partial remission, patient’s and physician’s global assessment scores (based on the comparison of ROC curves). ASDAS cut-off values are quite similar between groups indicating that ASDAS-CRP works similarly well in nr-axSpA and AS. The performance of ASDAS to discriminate low and high disease activity and cut-off values are quite similar in patients with AS and non-radiographic axial SpA. © 2014, Springer-Verlag Berlin Heidelberg.
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    Adaptation of emotional intelligence IPIP scales into turkish and examination of its psychometric properties; [UKMH duygusal zeka testinin türkçeye uyarlanması ve psikometrik özelliklerinin incelenmesi]
    (Cukurova University, Faculty of Medicine, 2016) Tatar A.; Saltukoğlu G.; Tok S.; Bender M.T.
    Objective: Turkish emotional intellinge scales are few, and Emotional Intelligence Test (IPIP-EIT) has several favorable features due to its large item pool, International Personality Item Pool, it was developed. The aim of this study is to adopt IPIP-EIT into Turkish and to examine the scale's psychometric properties. Methods: A thousand seven hundred fifty-four people ranging in age from 18 to 80 participated in the study. Out of these participants 211 people ranging in age from 18 to 63 took place in the test-retest study. Results: Alpha internal consistency coefficients of the main application of the test were as follows: 0.64 for attending emotions, 0.71 for emotion based decision making, 0.57 for emphatic concern, 0.58 for negative expressivity, 0.70 for positive expressivity, 0.61 for responsive distress, and 0.59 for responsive joy. Alpha internal consistency coefficient for the entire scale was 0.86. Correlations coefficients between the test and retest scores ranged from 0.67 to 0.80 for the subscales and it was 0.81 for the entire scale. Confirmatory factor analysis of the test showed seven dimensional single level factor structure. Its selected fit indexes were found as follows: goodness of fit index 0.95, adjusted goodness of fit index 0.92, root mean square error 0.003, and root mean square error of approximation 0.09. Examination of items based on item-response theory suggested that while some items had high discriminant power, others had low discriminant power. Conclusion: Results of the present study indicates that even though Turkish adaptation of the IPIPEmotional Intelligence Test has not a very strong structure, it can be considered as a valid and reliable device to measure emotional intelligence. © 2016, Cukurova University, Faculty of Medicine. All rights reserved.
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    Clinical performance of rheumatoid arthritis impact of disease score: a real-life evidence from the multicenter nationwide registry BioStaR
    (Springer Science and Business Media Deutschland GmbH, 2021) Melikoglu M.A.; Ataman S.; Bodur H.; Cay H.F.; Capkin E.; Akgul O.; Cevik R.; Gogus F.; Kamanli A.; Yurdakul F.G.; Gurer G.; Yagci I.; Rezvani A.; Duruoz M.T.; Sunar I.
    The rheumatoid arthritis impact of disease (RAID) score was developed as a patient-derived composite response index for the evaluation of the disease impact on cases with rheumatoid arthritis (RA). The aim of this study was to evaluate the psychometric properties and performance of RAID score in the real-life settings. Cases with RA from our multi-center, nationwide registry called Biologic and targeted Synthetic antirheumatic drugs Registry RA (BioStaR RA) were included in this cross-sectional observational study. Demographic data, disease duration, pain, patient’s global assessment (PGA) and physician’s global assessment (PhyGA) were recorded. DAS28-ESR, DAS28-CRP, the simplified disease activity index (SDAI) and the clinical disease activity index (CDAI) were assessed as disease activity evaluations. The health assessment questionnaire-disability index (HAQ-DI) and RAID were completed by all the participants. The construct validity was tested by the analysis of correlations between RAID score and scores of PGA, disease activity indexes and HAQ-DI. We also evaluated the discriminatory ability of RAID to distinguish patients with different levels of disease activity and disability and the cut-off values were calculated by ROC analysis. 585 cases with RA were included in this investigation. The RAID score was significantly positively correlated with PGA, all disease activity indexes and HAQ-DI (p < 0.001). The discriminatory ability of RAID score in different disease activity and disability groups was also demonstrated (p < 0.001). To estimate DAS28-ESR (remission/low + moderate + high), RAID score cut-off points were 2.88 (sensitivity 73%, specificity 62%), 3.23 (sensitivity 75%, specificity 60%) and 3.79 (sensitivity 74%, specificity 58%), respectively. Our study indicated that RAID was a reliable tool in daily clinical practice by presenting its correlations with disease activity and disability assessments and by showing its discriminatory ability in these parameters in the real-life experiences. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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    Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis
    (BMJ Publishing Group, 2021) Li Z.; Wu X.; Leo P.J.; De Guzman E.; Akkoc N.; Breban M.; MacFarlane G.J.; Mahmoudi M.; Marzo-Ortega H.; Anderson L.K.; Wheeler L.; Chou C.-T.; Harrison A.A.; Stebbings S.; Jones G.T.; Bang S.-Y.; Wang G.; Jamshidi A.; Farhadi E.; Song J.; Lin L.; Li M.; Wei J.C.-C.; Martin N.G.; Wright M.J.; Lee M.; Wang Y.; Zhan J.; Zhang J.-S.; Wang X.; Jin Z.-B.; Weisman M.H.; Gensler L.S.; Ward M.M.; Rahbar M.H.; Diekman L.; Kim T.-H.; Reveille J.D.; Wordsworth B.P.; Xu H.; Brown M.A.
    Objective We sought to test the hypothesis that Polygenic Risk Scores (PRSs) have strong capacity to discriminate cases of ankylosing spondylitis (AS) from healthy controls and individuals in the community with chronic back pain. Methods PRSs were developed and validated in individuals of European and East Asian ethnicity, using data from genome-wide association studies in 15 585 AS cases and 20 452 controls. The discriminatory values of PRSs in these populations were compared with other widely used diagnostic tests, including C-reactive protein (CRP), HLA-B27 and sacroiliac MRI. Results In people of European descent, PRS had high discriminatory capacity with area under the curve (AUC) in receiver operator characteristic analysis of 0.924. This was significantly better than for HLA-B27 testing alone (AUC=0.869), MRI (AUC=0.885) or C-reactive protein (AUC=0.700). PRS developed and validated in individuals of East Asian descent performed similarly (AUC=0.948). Assuming a prior probability of AS of 10% such as in patients with chronic back pain under 45 years of age, compared with HLA-B27 testing alone, PRS provides higher positive values for 35% of patients and negative predictive values for 67.5% of patients. For PRS, in people of European descent, the maximum positive predictive value was 78.2% and negative predictive value was 100%, whereas for HLA-B27, these values were 51.9% and 97.9%, respectively. Conclusions PRS have higher discriminatory capacity for AS than CRP, sacroiliac MRI or HLA-B27 status alone. For optimal performance, PRS should be developed for use in the specific ethnic groups to which they are to be applied. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.