Discriminant validity of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis: A cohort study
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2015
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Abstract
The aim of this study was to assess discriminant validity of Ankylosing Spondylitis Disease Activity Score (ASDAS)-C-reactive protein (-CRP) and ASDAS-erythrocyte sedimentation rate (-ESR) and to compare with The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) as clinical tools for the measurement of disease activity in patients with non-radiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS). Also, the cut-off values for ASDAS-CRP in nr-axSpA and AS is revisited. Patients with axSpA were recruited from Erciyes Spondyloarthritis Cohort (ESPAC) and were assessed for disease activity, quality of life and functional measures. The discriminatory ability of ASDAS-CRP and ASDAS-ESR was assessed using standardized mean differences and receiver operating characteristic (ROC) curves analysis. Optimal cut-off values for disease activity scores were calculated. Two hundred and eighty-seven patients with axSpA (nr-axSpA:132, AS:155) were included in this study. Two ASDAS versions and BASDAI had good correlations with patient’s and physician’s global assessment in both groups. Discriminatory ability of ASDAS-CRP, ASDAS-ESR and BASDAI were similar in patients with nr-axSpA and AS when the patients were assigned into low and high disease activity according to the ASAS partial remission, patient’s and physician’s global assessment scores (based on the comparison of ROC curves). ASDAS cut-off values are quite similar between groups indicating that ASDAS-CRP works similarly well in nr-axSpA and AS. The performance of ASDAS to discriminate low and high disease activity and cut-off values are quite similar in patients with AS and non-radiographic axial SpA. © 2014, Springer-Verlag Berlin Heidelberg.
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Adult , Area Under Curve , Biomarkers , Blood Sedimentation , C-Reactive Protein , Decision Support Techniques , Diagnosis, Differential , Discriminant Analysis , Female , Health Status , Humans , Inflammation Mediators , Male , Pain Measurement , Predictive Value of Tests , Quality of Life , Reproducibility of Results , ROC Curve , Severity of Illness Index , Spondylarthritis , Spondylitis, Ankylosing , Surveys and Questionnaires , C reactive protein , methotrexate , nonsteroid antiinflammatory agent , tumor necrosis factor alpha inhibitor , autacoid , biological marker , C reactive protein , adult , ankylosing spondylitis , Ankylosing Spondylitis Disease Activity Score , area under the curve , Article , Bath ankylosing spondylitis disease activity index , Bath ankylosing spondylitis functional index , clinical feature , cohort analysis , comparative effectiveness , controlled study , discriminant validity , disease activity score , erythrocyte sedimentation rate , female , human , major clinical study , male , non radiographic axial spondyloarthritis , non radiographic axial spondyloarthritis , prevalence , priority journal , quality of life , receiver operating characteristic , sensitivity and specificity , spondylarthritis , visual analog scale , blood , comparative study , decision support system , differential diagnosis , discriminant analysis , erythrocyte sedimentation rate , health status , immunology , pain measurement , predictive value , questionnaire , reproducibility , severity of illness index , spondylarthritis , Spondylitis, Ankylosing , validation study