Browsing by Subject "lansoprazole"

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    The effect of CagA status on response to Helicobacter pylori eradication therapy in Western Turkey
    (Associacao Brasileira de Divulgacao Cientifica, 2001) Saruç M.; Goksel G.; Ozkaya S.; Guclu F.; Ozbakkaloglu B.; Yuceyar H.
    If cytotoxin-associated gene A (CagA) status affects the response rates of therapy, then it may be possible to predict Helicobacter pylori eradication rates. We aimed to evaluate the response to eradication treatment of H. pylori infection in CagA-positive and CagA-negative patients. A total of 184 patients (93 males, 91 females, mean age 42.6 ± 12.8 years) with H. pylori-positive chronic gastritis were studied. Subjects underwent a gastroscopy and biopsy specimens were taken from the gastric antrum, body, and fundus. Before the eradication therapy was given all patients were tested for CagA, TNF-α and gastrin levels. They were then prescribed lansoprazole (30 mg bid), clarithromycin (500 mg bid), and amoxicillin (1.0 mg bid) for one week. On the 8th week a second endoscopy was performed and further biopsy specimens were obtained from the same sites as in the initial endoscopy. One hundred and twenty-seven patients (69.1%) were found to be CagA positive and 57 patients (30.9%) were CagA negative. The total eradication rate was 82.6%. In the CagA-positive group this rate was 87.4%, and in the CagA-negative group it was 71.9% (P = 0.019). TNF-α levels were higher in the CagA-positive than in the CagA-negative group (P = 0.001). However, gastrin levels were not different between groups (P = 0.421). Our findings revealed that CagA-negative status might be a risk factor for failure of H. pylori triple therapies. The CagA pathogenicity island gives a growth advantage to H. pylori strains and has been associated with an increase in the inflammatory response at the gastric mucosal level. These properties could make CagA-positive H. pylori strains more susceptible to antibiotics.
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    Prevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]
    (2003) Demet M.M.; Deniz F.; Şimşek E.; Taşkin E.O.; Deveci A.
    Objective: In this study, it is aimed to determine the prevalence of prescribing of psychotropic drugs and the combination of these drugs with the others, and to evaluate these combinations in terms of cytochrome p450 system interactions. Method: Out of 105 pharmacies in Manisa downtown area, fifty were visited. The sample consisted of 2164 prescriptions which had more than one drug. The combinations involved were recorded to a database and were evaluated according to cytochrome p450 system in terms of drug-drug interactions. Results: Of the whole prescriptions, 16.6% (360) had one or more psychotropic drug and the antidepressants were in first rank (9.3%) among psychotropic drugs. The number of prescriptions having any combination with possible drug-drug interactions was 19 (0.87% of the whole sample and 5.27% of the prescriptions which had psychotropic drug). Conclusion: It is a pleasing result that the amount of prescriptions that had possible drug-drug interactions in terms of cytochrome p450 system was small. Moreover, it is important that this study calls attention to possible drug interactions in terms of cytochrome system in addition to determine the present condition.
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    Frequency of gastroesophageal reflux disease in nonatopic children with asthma-like airway disease
    (2006) Yüksel H.; Yilmaz O.; Kirmaz C.; Aydogdu S.; Kasirga E.
    Gastroesophageal reflux disease (GERD) is commonly associated with asthma; however, frequency in nonatopic children with asthmatic symptoms is unknown. The aim of this study was to determine the frequency of gastroesophageal reflux (GER) in nonatopic children with asthma-like airway disease that recur despite conventional asthma treatment and to evaluate the clinical response to lansoprazole treatment. Twent-five nonatopic children aged between 1 and 16 years who have asthma-like airway disease and 25 healthy children were included in the study. All cases underwent 24 h pH monitoring with dual sensor catheters. Additionally, acid suppressor treatment was administered to patients diagnosed as having GERD and clinical response was evaluated. Major symptoms encountered in the patient group included wheezing and cough (88%, and 32%, respectively). Reflux episodes were more common in distal esophagus during the prone position (reflux index (RI) of 11.5±10.3 vs. 16.2±9.4 during supine vs. prone). All distal esophageal parameters were significantly higher in the patient group except number of reflux episodes lasting longer than 5 min (RI of 13.3±13.1 vs. 3.9±2.9 in the patient vs. control groups, respectively). There was a significant improvement in symptoms and requirement for medication with treatment (number of systems decreased from 2.3±0.6 to 0.4±0.6, P = 0.00). In conclusion, GERD is significantly more common in nonatopic children with asthma-like airway disease compared to the controls and clinical improvement is significant after acid suppressor treatment. Thus, we suggest that children followed-up with the diagnosis of nonatopic asthma with recurrent exacerbations despite adequate asthma treatment have a high frequency of GER and that lansoprazole treatment may be considered early in management. © 2005 Elsevier Ltd. All rights reserved.
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    Clinical significance of lung perfusion defects in children with post-infectious bronchiolitis obliterans
    (2009) Yüksel H.; Yilmaz Ö.; Ürk V.; Yüksel D.; Göktan C.; Savaş R.; Sayit E.
    Clinical significance of segmental lung perfusion defects in children with bronchiolitis obliterans (BO), have not been reported before. The aim of this study was to evaluate clinical significance of lung perfusion defects in children with BO and to reveal its impact on follow up. The study included 38 children aged 9 to 60 months (17.8 ± 13.4 months) with BO. Diagnosis was based on persistent respiratory findings beyond six weeks and oligemic-mosaic pattern in lung high resolution computerized tomography. Chest X-ray, 24 hour esophageal pH monitoring, sweat chloride test, immunoglobulin levels and respiratory viral screening were carried out in all. Lung perfusion scintigraphy was carried out at least three months after the first clinical sign of BO. Perfusion defects were scored. Scintigraphy demonstrated perfusion defects in 24 (63.2%) patients but was normal in 14 (36.8%). Number of segments having perfusion defects was 2.9 ± 2.6. Mean number of exacerbations and days of hospitalization during the first year of follow up were 4.7 ± 4.4 and 26.9 ± 29.8 respectively. It was detected that number of perfusion defects correlated significantly with the number of exacerbations and duration of hospitalization (r= 0.66 and p= 0.00). In conclusion, number and extent of segments with perfusion defects in lungs of children with BO are correlated with clinical severity. Therefore, evaluation of lung perfusion status may aid in clinical determination of disease severity and its follow-up.
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    Diagnostic value of stool antigen and antibody tests for Helicobacter pylori infection in Turkish children with upper gastrointestinal complaints before and after eradication
    (2010) Tiryaki Z.; Yilmaz-Çiftdoǧan D.; Kasirga E.
    The aim of this study was to evaluate the diagnostic value of Helicobacter pylori stool antigen (HpSA) and serologic tests before and after eradication therapy for H. pylori in Turkish children in our region with upper gastrointestinal complaints. In this study, 87 children with upper gastrointestinal complaints and 95 children with various symptoms without gastrointestinal complaints were enrolled. H. pylori infection was detected by urea breath test (UBT). HpSA and H. pylori immunoglobulin G (HpIgG) tests were applied to all the children. Eradication treatment was given to the 34 H.pyfon'-positive children. The UBT was positive in 43 of 87 children (49.4%) with upper gastrointestinal complaints. The sensitivity and specificity of the HpSA in children with upper gastrointestinal complaints were 86% and 84.1%, respectively, and those for the HpIgG were 76.7% and 90.9%, respectively. After eradication, the overall HpSA test sensitivity and specificity values were detected as 88.9% and 84%, respectively, and those for the HpIgG were 77.8% and 36%, respectively. The HpSA test is highly sensitive and specific for the diagnosis of H. pylori and for confirming eradication in Turkish children with upper gastrointestinal complaints. However, serology is not a reliable method for the diagnosis of H. pylori infection or for confirming eradication in children.
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    A patient with Bartter syndrome accompanying severe growth hormone deficiency and focal segmental glomerulosclerosis
    (2010) Akil I.; Ozen S.; Kandiloglu A.R.; Ersoy B.
    Bartter syndrome is a rare autosomal recessive, salt-losing disorder characterized by hypokalemic hypochloremic metabolic alkalosis. A 10-year-old boy had severe growth retardation (height standard deviation score - 8.15). He had a thin, triangular face, prominent ears and forehead, and big eyes. Megacystis, bilateral hydroureteronephrosis, and residual urine were detected in ultrasonography, but there was no vesicoureteral reflux. Lumbosacral magnetic resonance (MR) showed posterior disc bulging at L4-5. Serum sodium and chloride levels were normal, but mild hypokalemia was overlooked initially. During follow-up, hypokalemic hypochloremic metabolic alkalosis developed, with high urinary chloride and potassium excretion (52 and 43 mEq/L, respectively). The patient, with renal salt loss, was thought to have classic Bartter syndrome due to absence of nephrocalcinosis, presence of persistent hypercalciuria and sensorineural deafness, and presence of relatively mild clinical and laboratory findings, except polyuria initially. The child was treated with indomethacin, spironolactone, and oral potassium in addition to growth hormone (GH). During treatment, he had considerable increase in weight and height compared with the period of GH therapy only. We present this case because, although growth retardation is a major feature of Bartter syndrome, associated GH deficiency is rarely reported in the literature. Diagnosis of Bartter syndrome was made later, as our patient was followed for megacystis and megaureter secondary to the neurogenic bladder and GH deficiency initially; and proteinuria associated with focal segmental glomerulosclerosis responded to treatment for Bartter syndrome.
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    Idiopathic chest pain in children: Is it gastroesophageal reflux disease?
    (Ortadog u Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2016) Çetin M.; Yurttaş Ö.; Gözkeser E.; Coşkun Ş.; Kasirga E.
    Objective: Causes of chest pain in children, rarely due to cardiac disease and usually described as idiopathic, account for 20% to 45% of all cases. In this study, we investigated the frequency of gastroesophageal reflux in children with noncardiac chest pain and the characteristics of the pain. Material and Methods: Children with at least two episodes per month of chest pain for a maximum of six months were enrolled in the study. After diagnostic evaluation excluded a cardiac source of chest pain, all patients underwent 24-hour pH monitoring. Characteristics of chest pain and other symptoms were recorded daily by the patients or their parents using the symptom diary. Lansoprazole treatment was administered to patients diagnosed as having gastroesophageal reflux disease. Then, the results of the lansoprazole treatment were evaluated on the basis of the presence of chest pain and other symptoms at the second month after the completion of therapy. Results: Thirty-one children (17 boys and 14 girls) aged between eight and 18 years (11.6±2.4 years) with the primary complaint of chest pain were studied. Based on the 24-hour pH monitoring test results, eight patients (25.8%) for distal sensor and six patients (19.4%) for proximal sensor were defined as Gastroesophageal Reflux Disease (GERD)-positive. No significant difference was noted for characteristics of chest pain and other symptoms between the GERD-positive and GERD-negative groups. All GERD-positive children became symptom-free after the two-month lansoprazole therapy. Conclusion: The symptoms of GERD-induced chest pain are often non-specific, and can be determined with certainty only by 24-hour pH monitoring, so 24-hour pH monitoring may proposed to all children with idiopathic chest pain. Copyright © 2016 by Tür ki ye Kli nik le ri.
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    The role of endoplasmic reticulum stress in gastroesophageal reflux disease symptoms and treatment
    (AVES, 2023) Kasap E.; Buran T.; Avcu A.T.; Hasdemir P.S.; Balcan E.; Aktan C.; Korkmaz M.
    Background: Gastroesophageal reflux disease is a common condition worldwide. There is no curative treatment for gastroesophageal reflux disease. Endoplasmic reticulum stress leads to the activation of the unfolded protein response and has an important role in inflammation. The aim is to determine the role of endoplasmic reticulum stress in the follow-up of individuals with gastroesophageal reflux disease and the temporal changes of endoplasmic reticulum stress markers with treatment. Methods: Twenty-four subjects in total were recruited prospectively, of whom 15 had nonerosive reflux disease. Two biopsies from 2 cm above the esophagogastric junction, 2 biopsies from gastric antrum mucosa, and 2 biopsies from gastric corpus mucosa were taken. Simultaneously, 2 tubes of venous blood samples were drawn from each individual (1 tube for studying the genetic markers and 1 tube for analyzing the CYP2C19 polymorphism). Results: The mean age was 42.3 ± 17.6 for women and 34.66 ± 11.2 for men. Pantoprazole, esomeprazole, rabeprazole, and lansoprazole preparations were used for treatment. There was no significant difference between tissue and blood samples for panel genes ATF-6, XBP-1, DDIT-3, DNAJC-10, and EIF-2-AK before treatment. There was a significant decrease in the level of ATF-6, XBP-1, DNAJC-9, EIF-2-AK, and NF-2L-2 genes in blood after treatment. In the comparison of proton pump inhibitors, significant decreases in the expression of the ATF-6, XBP-1, and DNAJC-9 mRNAs were detected in blood from individuals after treatment. Conclusion: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastroesophageal reflux disease. © 2023 AVES. All rights reserved.