Prevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]

Demet M.M.; Deniz F.; Şimşek E.; Taşkin E.O.; Deveci A.

Prevalence of prescription of psychotropic drugs and drug-drug interactions: The cytochrome P450 system; [Psikotrop i̇laç yazilma sikliǧi ve i̇laç etkileşimleri: Sitokrom P450 sistemi]

Date

2003

Authors

Abstract

Objective: In this study, it is aimed to determine the prevalence of prescribing of psychotropic drugs and the combination of these drugs with the others, and to evaluate these combinations in terms of cytochrome p450 system interactions. Method: Out of 105 pharmacies in Manisa downtown area, fifty were visited. The sample consisted of 2164 prescriptions which had more than one drug. The combinations involved were recorded to a database and were evaluated according to cytochrome p450 system in terms of drug-drug interactions. Results: Of the whole prescriptions, 16.6% (360) had one or more psychotropic drug and the antidepressants were in first rank (9.3%) among psychotropic drugs. The number of prescriptions having any combination with possible drug-drug interactions was 19 (0.87% of the whole sample and 5.27% of the prescriptions which had psychotropic drug). Conclusion: It is a pleasing result that the amount of prescriptions that had possible drug-drug interactions in terms of cytochrome p450 system was small. Moreover, it is important that this study calls attention to possible drug interactions in terms of cytochrome system in addition to determine the present condition.