Browsing by Subject "lipoprotein metabolism"

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    Increased lipoprotein (a) and its relationships with other parameters of lipoprotein metabolism in chronic renal failure treated by hemodialysis
    (International Heart Journal Association, 1997) Ramazan Yiǧitoǧlu M.; Fevzi Polat M.; Akçay F.; Ari Z.; Sami Uyanik B.; Özilgili H.M.
    Background. Studies have shown that patients with chronic renal failure have a high frequency of cardiocascular atheromatous disease. Methods. We examined serum lipoprotein (a) [Lp(a)], very-low density lipoprotein cholesterol (VLDL-C), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (apo A1) and B (apo B), triglyceride (TG) and total cholesterol (TC) levels as possible risk factors for atherosclerosis in 45 patients with chronic renal failure (CRF) treated by hemodialysis (HD) and in 15 CRF patients who were not on HD. A control group of 20 healthy subjects was also studied. Results. The proportion of smokers and body mass indexes were similar between the groups. In both patient groups, higher TG, TC and Lp(a) and lower apo A1 and HDL-C levels in serum were found than in those of controls. Serum apo B and LDL-C were similar in the patients treated by HD and the controls. Serum VLDL-C and LDL-C were similar in the CRF patients who were not on HD and the controls. The highest ratios of apo B/apo A1 and LDL-C/HDL-C were found in HD patients. The highest ratio of TC/HDL-C was found in the other patient group. We found significant correlations between Lp(a) and other parameters of lipoprotein metabolism in CRF patients, both those who were and those who were not on HD. Conclusions. Our results indicate that CRF patients who both were and were not on HD show atherogenic changes in the lipoprotein pattern, and that the increase in Lp(a) during the CRF phase is basically related to the loss of renal function and may also depend on the resultant alterations which are produced in other lipoprotein variables.
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    The association of apolipoprotein e polymorphism and lipid levels in children with a family history of premature coronary artery disease
    (2012) Çiftdoǧan D.Y.; Coskun S.; Ulman C.; T́ykýz H.
    Background: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, they have been associated with relative risk of coronary artery disease (CAD). Objective: To evaluate the association of apolipoprotein E polymorphism and lipid levels in children with family history of premature coronary artery disease. Methods: The apoE genotypes, allele frequencie,s and plasma lipid levels were analyzed in 137 children. Among these children, 70 (study group) had and 67 (control group) did not have a parental history of premature CAD Results: Total cholesterol (Tc) levels were greater in the study group (P =.04). The frequencies of ε3ε4 genotype and ε4 allele were significantly greater in the study group (P = 005 for both), Thε ε2 allele correlated negatively with Tc and low-density lipoprotein cholesterol levels, and ε4 had a positive correlation with Tc and low-density lipoprotein cholesterol levels. Conclusions: Tc levels are influenced by apoE genotypes in childhood. Also, the frequency of the ε4 allele is greater in children with family history of premature CAD. The ε4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of Tc in children with family history of CAD. The evaluation of apoE gene polymorhisms may contribute to the assessment of cardiovascular risk in children with a family history of CAD. © 2012 National Lipid Association. All rights reserved.