The association of apolipoprotein e polymorphism and lipid levels in children with a family history of premature coronary artery disease
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2012
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Abstract
Background: Polymorphisms in the apolipoprotein E (apoE) gene may modulate lipoprotein metabolism and influence plasma lipid levels. Thus, they have been associated with relative risk of coronary artery disease (CAD). Objective: To evaluate the association of apolipoprotein E polymorphism and lipid levels in children with family history of premature coronary artery disease. Methods: The apoE genotypes, allele frequencie,s and plasma lipid levels were analyzed in 137 children. Among these children, 70 (study group) had and 67 (control group) did not have a parental history of premature CAD Results: Total cholesterol (Tc) levels were greater in the study group (P =.04). The frequencies of ε3ε4 genotype and ε4 allele were significantly greater in the study group (P = 005 for both), Thε ε2 allele correlated negatively with Tc and low-density lipoprotein cholesterol levels, and ε4 had a positive correlation with Tc and low-density lipoprotein cholesterol levels. Conclusions: Tc levels are influenced by apoE genotypes in childhood. Also, the frequency of the ε4 allele is greater in children with family history of premature CAD. The ε4 allele may be associated with an increased risk for development of atherosclerosis by elevated levels of Tc in children with family history of CAD. The evaluation of apoE gene polymorhisms may contribute to the assessment of cardiovascular risk in children with a family history of CAD. © 2012 National Lipid Association. All rights reserved.
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Adolescent , Alleles , Apolipoprotein E4 , Case-Control Studies , Child , Child, Preschool , Cholesterol , Cholesterol, LDL , Coronary Artery Disease , DNA Mutational Analysis , Female , Gene Frequency , Genetic Association Studies , Genotype , Humans , Male , Polymorphism, Genetic , apolipoprotein E , cholesterol , lipid , low density lipoprotein , adolescent , article , atherosclerosis , cardiovascular risk , child , childhood disease , cholesterol blood level , controlled study , coronary artery disease , correlational study , disease association , family history , female , gene frequency , genetic polymorphism , genetic risk , genotype , human , lipid blood level , lipoprotein metabolism , major clinical study , male , medical history , premature coronary artery disease , priority journal , school child