Browsing by Subject "retina macula cystoid edema"

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    Intravitreal Dexamethasone Implant in Retinitis Pigmentosa-related Cystoid Macular Edema
    (Lippincott Williams and Wilkins, 2018) Mansour A.M.; Sheheitli H.; Kucukerdonmez C.; Sisk R.A.; Moura R.; Moschos M.M.; Lima L.H.; Al-Shaar L.; Arevalo J.F.; Maia M.; Foster R.E.; Kayikcioglu O.; Kozak I.; Kurup S.; Zegarra H.; Gallego-Pinazo R.; Hamam R.N.; Bejjani R.A.; Cinar E.; Erakgün E.T.; Kimura A.; Teixeira A.
    Purpose: To report the clinical outcome after intravitreal dexamethasone implant in patients with retinitis pigmentosa and cystoid macular edema. Methods: Multicenter retrospective case series of eyes with retinitis pigmentosa and cystoid macular edema that underwent intravitreal dexamethasone implant. Primary outcome measures were best-corrected visual acuity in LogMAR and central macular thickness. Statistical analyses used two-tailed comparison with Wilcoxon signed-rank test. Results: There were a total of 45 eyes from 34 patients with a mean age of 32.7 years (range 16-57) and mean follow-up of 15.5 ± 13.0 months. At Month 3 after the first injection, mean initial best-corrected visual acuity improved from 0.61 ± 0.38 (20/81) to 0.37 ± 0.16 (20/47) (P = 0.012), whereas mean central macular thickness (m) decreased from 506 ± 288 m to 311.7 ± 71.6 m (P < 0.001) and mean intraocular pressure increased from 15.7 ± 2.3 mmHg to 19.8 ± 11.0 mmHg (P = 0.01). Fourteen eyes had multiple injections (1-7 reinjections) at a mean interval of 6 months. Treatment effect was durable with multiple injections, but with seven eyes developing visually significant cataracts. Conclusion: Best-corrected visual acuity improved up to 4 months in around half of the eyes. Eyes that benefited the most were pseudophakic, steroid nonresponsive, with large initial central macular thickness, and profuse fluorescein dye leakage. © Ophthalmic Communications Society, Inc.
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    Efficacy of topical brinzolamide treatment in posterior microphthalmos-related macular cystoid lesions: A case series
    (Turkish Ophthalmology Society, 2020) Engin C.D.; Ekinci U.B.; Selver A.; Saatçi A.O.
    The aim of this study was to report the outcome of topical brinzolamide 1% treatment on macular cystoid lesions resembling retinoschisis in 4 patients diagnosed with posterior microphthalmia. The medical records of 4 patients with a clinical diagnosis of posterior microphthalmia who had started topical brinzolamide 1% treatment were reviewed. Visual acuity, central foveal thickness, and cystoid lesion area percentage were used to evaluate treatment response. In the follow-up, there was a decrease in central foveal thicknesses and cystoid lesion area percentages in both eyes of 3 of the patients. However, 1 patient showed increases in both parameters. Visual acuity remained stable in 5 eyes and increased in 3 eyes. Topical brinzolamide treatment may have some positive effects on macular cystoid lesions in selected cases. © 2020 by Turkish Ophthalmological Association Turkish Journal of Ophthalmology, published by Galenos Publishing House.