Browsing by Subject "uterine tube toxicity"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
Item Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity(Taylor and Francis Ltd, 2016) Saribas G.S.; Erdogan D.; Goktas G.; Akyol S.N.; Hirfanoglu I.M.; Gurgen S.G.; Coskun N.; Ozogul C.The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin. © 2016 Informa UK Limited, trading as Taylor & Francis Group.