Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity
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Date
2016
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Abstract
The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
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Keywords
Acetylcarnitine , Animals , Antineoplastic Agents , Cisplatin , Fallopian Tubes , Female , Protective Agents , Rats , Rats, Wistar , Vitamin B Complex , caspase 3 , caspase 8 , caspase 9 , cisplatin , levacecarnine , acetylcarnitine , antineoplastic agent , cisplatin , protective agent , vitamin B complex , adult , animal cell , animal experiment , animal model , animal tissue , Article , body weight , controlled study , Fallopian tube , female , immunohistochemistry , immunoreactivity , lymphocyte , nonhuman , priority journal , prophylaxis , protein expression , rat , secretory cell , toxicity , TUNEL assay , uterine tube disease , uterine tube toxicity , weight reduction , Wistar rat , animal , drug effects , pathology