The effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages

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dc.contributor.authorTaneli, F
dc.contributor.authorErsoy, B
dc.contributor.authorÖzhan, B
dc.contributor.authorÇalkan, M
dc.contributor.authorYilmaz, Ö
dc.contributor.authorDinç, G
dc.contributor.authorGenç, A
dc.contributor.authorTaneli, C
dc.date.accessioned2024-07-18T11:47:17Z
dc.date.available2024-07-18T11:47:17Z
dc.description.abstractObjectives: The aim of the present study is to investigate the effect of obesity on testicular function by evaluating reproductive hormones, inhibinB, insulin-like 3(INSL3), and leptin, in obese and non-obese adolescents according to pubertal Tanner stages. Design and methods: Eighty adolescent boys were grouped (n = 20) as; Group1 : obese-Tanner2, Group2: non-obese-Tanner2, Group3: obese-Tanner4, Group4: non-obese-Tanner4. Serum INSL3, luteinizing hormone, follicle-stimulating hormone, total testosterone, free testosterone, estradiol, sex hormone binding globulin, inhibin B and leptin levels were assessed in all groups. Results: INSL3 levels were significantly lower in obese adolescents compared to non-obese boys (p = 0.003, Tanner2) and (p = 0.031, Tanner4). There was a negative correlation between INSL3 and leptin (r = -0.468, p = 0.001). The negative correlation between INSL3 and BMISDS indicates that pubertal obesity leads to Leydig cell impairment. Conclusions: This study demonstrated for the first time in the literature that obesity effects testicular Leydig cell function starting from Tanner stage 2. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
dc.identifier.issn0009-9120
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3414
dc.language.isoEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectFOLLICLE-STIMULATING-HORMONE
dc.subjectLUTEINIZING-HORMONE
dc.subjectSEMEN QUALITY
dc.subjectOLDER MEN
dc.subjectSERUM
dc.subjectBOYS
dc.subjectAGE
dc.subjectTESTOSTERONE
dc.subjectAXIS
dc.subjectACTIVATION
dc.titleThe effect of obesity on testicular function by insulin-like factor 3, inhibin B, and leptin concentrations in obese adolescents according to pubertal stages
dc.typeArticle

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