Effect of propolis on endotoxin-induced uveitis in rabbits

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dc.contributor.authorÖztürk, F
dc.contributor.authorKurt, E
dc.contributor.authorInan, ÜÜ
dc.contributor.authorEmiroglu, L
dc.contributor.authorIlker, SS
dc.contributor.authorSobaci, G
dc.date.accessioned2024-07-18T11:54:25Z
dc.date.available2024-07-18T11:54:25Z
dc.description.abstractPurpose: To test the anti-inflammatory effect of propolis, a natural bee-produced compound, and compare it with corticosteroids fur the: treatment of endotoxin-induced uveitis (EIU). Methods: EIU was produced in all rabbits by unilateral intravitreal injection of 2,000 ng Salmonella typhimurium endotoxin. The animals were then divided randomly into three groups as follows: group A received no treatment (control), group B received methylprednisolone (5 mg/0.1 mL) (positive control); and group C received propolis (5 mg/0.16 mL) by anterior sub-Tenon injection at the time of uveitis induction and at 4 and 8 hours after induction. Inflammation was evaluated by clinical manifestations and by measuring the protein concentration and inflammatory cell content of the aqueous humor. Results: The clinical grade, cell count: and protein levels in the aqueous humor were: control group (6.0 +/- 0.8, 2,519 +/- 470 cells/mu L. 32.9 +/- 2.4 mg/mL); methylprednisolone group (1.8 +/- 0.7, 572 +/- 137 cells/mu L. 15.2 +/- 1.8 mg/mL); and propolis group (2.3 +/- 0.5, 503 +/- 124 cells/mu L, 13.8 +/- 1.5 mg/mL). Statistically significant differences were recorded in the treatment groups when compared to the control group (P < .001). The effects of methylprednisolone and propolIs on EIU were similar (P > .05). Conclusions: Propolis showed significant anti-inflammatory effects on EIU iii rabbits. The mechanism of its action warrants further investigation. Jpn J Ophthalmol 1999;43:285-289. (C) 1999 Japanese Ophthalmological Society.
dc.identifier.issn0021-5155
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6357
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectACID PHENETHYL ESTER
dc.subjectINFLAMMATORY RESPONSE
dc.subjectOCULAR INFLAMMATION
dc.subjectETHANOLIC EXTRACT
dc.subjectRATS
dc.subjectINHIBITION
dc.subjectPROPERTY
dc.subjectRADICALS
dc.titleEffect of propolis on endotoxin-induced uveitis in rabbits
dc.typeArticle

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