Expression profiles of histone modification genes in gastric cancer progression

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dc.contributor.authorOrenay-Boyacioglu S.
dc.contributor.authorKasap E.
dc.contributor.authorGerceker E.
dc.contributor.authorYuceyar H.
dc.contributor.authorDemirci U.
dc.contributor.authorBilgic F.
dc.contributor.authorKorkmaz M.
dc.date.accessioned2024-07-22T08:09:28Z
dc.date.available2024-07-22T08:09:28Z
dc.date.issued2018
dc.description.abstractGastric cancer (GC) development can be attributed to several risk factors including atrophic gastritis (AG), intestinal metaplasia (IM), and the presence of Helicobacter pylori (HP). Also, histone modification is an epigenetic mechanism that plays a pivotal role in GC carcinogenesis. In this preliminary study, we aimed to describe the expression profiles of histone modification in the AG, IM, and GC patient groups. A total of 80 patients with AG (n = 27), IM (n = 25), and GC (n = 28) with an additional 20 control subjects were included in the study. Expression profiles of three histone phosphorylation genes (PAK1, NEK6, and AURKA) and five histone deacetylation genes (HDACs 1, 2, 3, 5, and 7) were examined based on the results of Real Time qPCR method. It was observed that AURKA and HDAC2 genes were significantly overexpressed in all groups compared to the control (P < 0.05). In GC patients, overexpression of HDAC2 gene was detected in the absence of metastasis, and overexpression of AURKA, HDAC2, and NEK6 genes was detected in the presence of metastasis. When cancer involvements were compared, significant overexpression of the HDAC2 gene was noted in overall and corpus involvements (P < 0.05). In addition, overexpression of AURKA, NEK6, HDAC1, and HDAC2 genes and underexpression of HDAC5 gene were detected in the antrum involvement (P < 0.05). In conclusion, decreased expression of HDAC5 in GC is reported for the first time in this study, while supporting the existing literature in AURKA, NEK6, HDAC1, and HDAC2 up regulations during GC development. © 2018, Springer Nature B.V.
dc.identifier.DOI-ID10.1007/s11033-018-4389-z
dc.identifier.issn03014851
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14841
dc.language.isoEnglish
dc.publisherSpringer Netherlands
dc.subjectAdult
dc.subjectAged
dc.subjectAurora Kinase A
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectGastric Mucosa
dc.subjectGastritis, Atrophic
dc.subjectGenetic Variation
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHistone Code
dc.subjectHistone Deacetylases
dc.subjectHistones
dc.subjectHumans
dc.subjectIntestines
dc.subjectMale
dc.subjectMetaplasia
dc.subjectMiddle Aged
dc.subjectNIMA-Related Kinases
dc.subjectp21-Activated Kinases
dc.subjectPreliminary Data
dc.subjectRisk Factors
dc.subjectStomach
dc.subjectStomach Neoplasms
dc.subjectTranscriptome
dc.subjectaurora A kinase
dc.subjecthistone
dc.subjecthistone deacetylase 1
dc.subjecthistone deacetylase 2
dc.subjecthistone deacetylase 3
dc.subjecthistone deacetylase 5
dc.subjectp21 activated kinase 1
dc.subjectAURKA protein, human
dc.subjectHDAC5 protein, human
dc.subjecthistone
dc.subjecthistone deacetylase
dc.subjectNEK6 protein, human
dc.subjectNIMA related kinase
dc.subjectp21 activated kinase
dc.subjectPAK1 protein, human
dc.subjecttranscriptome
dc.subjectadult
dc.subjectArticle
dc.subjectatrophic gastritis
dc.subjectAURKA gene
dc.subjectcancer growth
dc.subjectcancer patient
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene
dc.subjectgene expression
dc.subjectgene expression profiling
dc.subjectgene overexpression
dc.subjectHDAC1 gene
dc.subjectHDAC2 gene
dc.subjectHDAC3 gene
dc.subjectHDAC5 gene
dc.subjectHDAC7 gene
dc.subjectHelicobacter pylori
dc.subjecthistone acetylation
dc.subjecthistone modification
dc.subjecthuman
dc.subjectintestine metaplasia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetastasis
dc.subjectNEK6 gene
dc.subjectPAK1 gene
dc.subjectpathogenesis
dc.subjectstomach antrum
dc.subjectstomach cancer
dc.subjectupregulation
dc.subjectaged
dc.subjectdisease exacerbation
dc.subjectgenetic variation
dc.subjectgenetics
dc.subjectHelicobacter infection
dc.subjecthistone code
dc.subjectintestine
dc.subjectmetaplasia
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectpreliminary data
dc.subjectrisk factor
dc.subjectstomach
dc.subjectstomach mucosa
dc.subjectstomach tumor
dc.titleExpression profiles of histone modification genes in gastric cancer progression
dc.typeArticle

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