Synthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)

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dc.contributor.authorÜnak, P
dc.contributor.authorMüftüler, FZB
dc.contributor.authorIçhedef, Ç
dc.contributor.authorMedine, EI
dc.contributor.authorÖzmen, K
dc.contributor.authorÜnak, T
dc.contributor.authorKilçar, AY
dc.contributor.authorGümüser, FG
dc.contributor.authorParlak, Y
dc.contributor.authorBilgin, ES
dc.date.accessioned2024-07-18T12:03:17Z
dc.date.available2024-07-18T12:03:17Z
dc.description.abstractDiethylstilbestrol (DES) is a well known, nonsteroidal estrogen with high affinity for the estrogen receptor (ER). Today DES is used to treat breast and prostate cancers. A phosphate derivative of DES [Diethylstilbestrol diphosphate (DES-P)] which is specific to tumor cells consisting alkaline phosphatase enzyme was synthesized and labeled with Tc-99m using tin chloride as reducing agent. In vivo biological activity of Tc-99m labeled diethylstilbestrol phosphate compound (Tc-99m-DES-P) was examined by biodistribution studies on Wistar Albino rats. Statistical evaluation was performed using SPSS 13 program. The percentage (%) radiolabeling yield of Tc-99m-DES-P and quality control studies were done by Thin Layer Radio Chromatography (TLRC). Results showed that, Tc-99m-DES-P may be proposed as an imaging agent for ER enriched tumors such as uterus and prostate and their metastases in bones.
dc.identifier.issn0236-5731
dc.identifier.other1588-2780
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9026
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectSPECTROPHOTOMETRIC DETERMINATION
dc.subjectALKALINE-PHOSPHATASE
dc.subjectFLOW-INJECTION
dc.subjectFOSFESTROL
dc.subjectGLUCURONIDE
dc.subjectINFUSION
dc.subjectTHERAPY
dc.subjectTUMORS
dc.subjectI-125
dc.titleSynthesis, radiolabeling and in vivo biodistribution of diethylstilbestrol phosphate derivative (DES-P)
dc.typeArticle

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