Molecular diversity of drug resistant Mycobacterium tuberculosis strains in Western Turkey
| dc.contributor.author | Sürücüoǧlu S. | |
| dc.contributor.author | Günal S. | |
| dc.contributor.author | Özkütük N. | |
| dc.contributor.author | Biçmen C. | |
| dc.contributor.author | Özsöz A. | |
| dc.contributor.author | Gazi H. | |
| dc.contributor.author | Durmaz R. | |
| dc.date.accessioned | 2025-04-10T11:14:59Z | |
| dc.date.available | 2025-04-10T11:14:59Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | Objective: The aim of this study was to investigate the molecular diversity and clonal relationship of drug resistant Mycobacterium tuberculosis strains isolated in Western Turkey. Materials and Methods: A total of 87 strains isolated between 2006 and 2009, eight of which were rifampicin monoresistant and 79 were multidrug resistant, were analyzed with IS6110 RFLP and spoligotyping methods. Results: The results of spoligotyping showed that 7% of the strains were orphans, and 8% were undefined for family in the SpolDB4 database. Major families of the strains were LAM (38%), T (35%), Haarlem (7%), Beijing (2%), S (2%) and U (1%) families. The clustering rate by spoligotyping was calculated as 75%. The most predominant SIT cluster was SIT41 (29%). According to the results of IS6110 RFLP, 71 different patterns of IS6110 were observed. Low copy number was found in 26% of the strains. When the results of two methods were combined, the final clustering rate was calculated as 26%. Conclusions: The genotypical distribution of drug resistant tuberculosis isolates in our region indicates genetic diversity and the clustering rate was found low in our region. However, more comprehensive and long-term molecular epidemiological studies are needed to control the drug resistant strains. © Trakya University Faculty of Medicine. | |
| dc.identifier.DOI-ID | 10.5152/balkanmedj.2012.012 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/50668 | |
| dc.publisher | Galenos Publishing House | |
| dc.title | Molecular diversity of drug resistant Mycobacterium tuberculosis strains in Western Turkey | |
| dc.type | Article |