Are Human Adenovirus-5 and 36 Associated With Obesity in Children?

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dc.contributor.authorCakmakliogullari, EK
dc.contributor.authorSanlidag, T
dc.contributor.authorErsoy, B
dc.contributor.authorAkcali, S
dc.contributor.authorVar, A
dc.contributor.authorCicek, C
dc.date.accessioned2024-07-18T12:02:51Z
dc.date.available2024-07-18T12:02:51Z
dc.description.abstractObjectives: The aims of this study were to determine the association between adenovirus-5- and adenovirus-36-specific antibodies and obesity in children and to investigate their relationship with serum lipid and leptin levels. Methods: A cross-sectional study was performed on a total of 120 children who were divided into subgroups according to body mass index percentile as obese (>= 95th percentile) or nonobese (<95th percentile). The presence of adenovirus-36 and adenovirus-5-neutralizing antibodies was investigated by using the serum neutralization assay. Serum leptin levels were determined by microenzyme immonoassay; high-density lipoprotein, low-density lipoprotein, triglyceride, and cholesterol levels were measured by chemiluminescence method. Results: The presence of adenovirus-5-specific antibodies was 28.3% and 6.6% in the obese children and in non-obese children, respectively (P = 0.02). The frequency of adenovirus-36-specific antibodies was significantly greater (P = 0.018) in the obese children (26.6%) than in the nonYobese children (10.0%). Serum leptin level of the obese group were significantly higher than that of the non-obese group (P = 0.000). Conclusions: Our data support the association between obesity and the presence of specific antibodies to adenovirus-36 and adenovirus-5 in children. Our research has the feature of being the first national study to indicate the relationship between adenovirus-36 and human obesity as well as the first international study to indicate the relationship between adenovirus-5 and human obesity.
dc.identifier.issn1081-5589
dc.identifier.other1708-8267
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8729
dc.language.isoEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.subjectADIPOSITY
dc.subjectOVERWEIGHT
dc.subjectWEIGHT
dc.titleAre Human Adenovirus-5 and 36 Associated With Obesity in Children?
dc.typeArticle

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