The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice
| dc.contributor.author | Inan S.Y. | |
| dc.contributor.author | Aksu F. | |
| dc.contributor.author | Baysal F. | |
| dc.date.accessioned | 2025-04-10T11:18:15Z | |
| dc.date.available | 2025-04-10T11:18:15Z | |
| dc.date.issued | 2000 | |
| dc.description.abstract | The effects of three K+ channel blockers, 4-aminopyridine, 3,4-diaminopyridine and apamin, on scopolamine- or electroconvulsive shock-induced amnesia were investigated in mice by using a one-trial step-down passive avoidance system. Scopolamine and electroconvulsive shock reduced the retention latency of passive avoidance, which indicated the amnestic effect of these treatments. 4-Aminopyridine, 3,4-diaminopyridine and apamin injected immediately after the acquisition trial, reversed the amnestic effect of scopolamine or electroconvulsive shock in a dose-dependent manner. None of the drugs or electroconvulsive shock treatment affected the rotarod or activity cage performance of the mice. These results indicate that K+ channel blockers may improve cognitive deficits when memory is impaired by a drug or any other manipulation. Copyright (C) 2000 Elsevier Science B.V. | |
| dc.identifier.DOI-ID | 10.1016/S0014-2999(00)00736-6 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/53299 | |
| dc.title | The effects of some K+ channel blockers on scopolamine- or electroconvulsive shock-induced amnesia in mice | |
| dc.type | Article |