Acute responses of strength-related gene expressions to maximum strength and force sense acuity

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dc.contributor.authorAltun, M
dc.contributor.authorBalcan, E
dc.contributor.authorBatir, S
dc.contributor.authorGökmen, MH
dc.contributor.authorÖzgünes, S
dc.contributor.authorÖztel, Z
dc.date.accessioned2024-07-18T11:53:22Z
dc.date.available2024-07-18T11:53:22Z
dc.description.abstractBackground/aim: Although high muscle strength worsens the sense of force, it is unknown whether there is a relationship between this deterioration and the underlying molecular mechanisms. This study examined the relationship between decreased force sense (FS) acuity and strength -related gene expressions. Materials and methods: Maximal voluntary isometric contraction (MVIC) and FS (50% MVIC) tests were performed on the knee joints of twenty-two subjects. The expression analyses were evaluated by qRT-PCR in blood samples taken before, after MVIC, after 50% MVIC, and 15 min after the test. Results: MVIC and FS error values were significantly correlated with each other (r = .659, p = .001). The qRT-PCR analyses demonstrated that the expressed mRNAs of the interleukin 6 (IL -6), alpha-actinin 3 (ACTN3), angiotensin-converting enzyme (ACE), brain -derived neurotrophic factor (BDNF), and ciliary neurotrophic factor receptor (CNTFR) genes dramatically increased until 50% MVIC and subsequently decreased 15 min after the exercise (p < .05). The muscle -specific creatine kinase (CKMM), myosin light chain kinase (MLCK), and G -protein beta 3 subunit (GNB3) genes reached their peak expression levels 30 min after MVIC (p < .05). ACE and ACTN3 gene expression increased significantly in parallel with the increased FS error (p < .05). These gene expression fluctuations observed at 50% MVIC and after the rest could be related to changes in cellular metabolism leading to fatigue. Conclusion: The time points of gene expression levels during exercise need to be considered. The force acuity of those whose maximal force develops too much may deteriorate.
dc.identifier.issn1300-0144
dc.identifier.other1303-6165
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5557
dc.language.isoEnglish
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.subjectCONVERTING-ENZYME GENE
dc.subjectNEUROTROPHIC FACTOR
dc.subjectPROPRIOCEPTION
dc.subjectPOLYMORPHISM
dc.subjectINTERLEUKIN-6
dc.subjectASSOCIATION
dc.subjectRELEASE
dc.subjectBRAIN
dc.titleAcute responses of strength-related gene expressions to maximum strength and force sense acuity
dc.typeArticle

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