Prenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung
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2008
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Abstract
The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 μg/kg) on day 16 of pregnancy. Rats were sacrificed on days 18 and 20 of gestation. H-score for VEGF was calculated immunohistochemically. Alveolar VEGF expression on days 18 and 20 of gestation was significantly higher in the GM-CSF group (P <.01). Increase in VEGF with prenatal GM-CSF administration indicates that GM-CSF may stimulate lung growth and maturation and may be protective against lung disease due to prematurity. Copyright © Informa Healthcare USA, Inc.
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Animals , Fetus , Gene Expression , Granulocyte Macrophage Colony-Stimulating Factors, Recombinant , Lung , Mesoderm , Rats , Rats, Wistar , Vascular Endothelial Growth Factor A , recombinant granulocyte colony stimulating factor , recombinant granulocyte macrophage colony stimulating factor , sodium chloride , vasculotropin , animal cell , animal experiment , animal tissue , article , controlled study , drug effect , female , fetus , fetus lung maturation , gestational age , growth stimulation , immunohistochemistry , lung development , lung disease , mesenchyme , nonhuman , pregnancy , prenatal period , priority journal , protein expression , rat