Prenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung

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dc.contributor.authorYuksel H.
dc.contributor.authorYilmaz O.
dc.contributor.authorBaytur Y.B.
dc.contributor.authorOzbilgin K.
dc.date.accessioned2024-07-22T08:22:06Z
dc.date.available2024-07-22T08:22:06Z
dc.date.issued2008
dc.description.abstractThe aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 μg/kg) on day 16 of pregnancy. Rats were sacrificed on days 18 and 20 of gestation. H-score for VEGF was calculated immunohistochemically. Alveolar VEGF expression on days 18 and 20 of gestation was significantly higher in the GM-CSF group (P <.01). Increase in VEGF with prenatal GM-CSF administration indicates that GM-CSF may stimulate lung growth and maturation and may be protective against lung disease due to prematurity. Copyright © Informa Healthcare USA, Inc.
dc.identifier.DOI-ID10.1080/01902140802341736
dc.identifier.issn15210499
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18924
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectFetus
dc.subjectGene Expression
dc.subjectGranulocyte Macrophage Colony-Stimulating Factors, Recombinant
dc.subjectLung
dc.subjectMesoderm
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectVascular Endothelial Growth Factor A
dc.subjectrecombinant granulocyte colony stimulating factor
dc.subjectrecombinant granulocyte macrophage colony stimulating factor
dc.subjectsodium chloride
dc.subjectvasculotropin
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectfemale
dc.subjectfetus
dc.subjectfetus lung maturation
dc.subjectgestational age
dc.subjectgrowth stimulation
dc.subjectimmunohistochemistry
dc.subjectlung development
dc.subjectlung disease
dc.subjectmesenchyme
dc.subjectnonhuman
dc.subjectpregnancy
dc.subjectprenatal period
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectrat
dc.titlePrenatal administration of granulocyte-macrophage colony-stimulating factor increases mesenchymal vascular endothelial growth factor expression and maturation in fetal rat lung
dc.typeArticle

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