Effects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study

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dc.contributor.authorÖztürk, F
dc.contributor.authorBabacan, H
dc.contributor.authorInan, S
dc.contributor.authorGümüs, C
dc.date.accessioned2024-07-18T12:05:23Z
dc.date.available2024-07-18T12:05:23Z
dc.description.abstractIntroduction: The aim of this experimental study was to evaluate the effects of systemically applied zoledronic acid on bone regeneration in response to expansion of the sagittal suture and relapse in rats. Methods: Thirty-six male Wistar rats were divided into 3 groups. In the first and second groups, saline solution was given subcutaneously after expansion, and the retention periods lasted 14 and 7 days, respectively. In the third group, 0.1 mg of zoledronic acid was diluted with saline solution and given subcutaneously after expansion; the retention period lasted for 7 days. Expansion and relapse amounts were measured by using computed tomography. After the retention period, 6 rats from each group were killed for histologic and immunohistochemical assessments. The other 6 rats from each group were used for observation of the relapse. Results: The histologic evaluation showed that, in groups 1 and 2, the numbers of osteoblasts were less than observed in group 3. When scores of staining intensity were compared, immunoreactivities were statistically significantly increased in group 3 compared with groups 2 and 1. Statistically significant differences were found when the relapse percentages were compared between the groups (P < 0.05). The smallest relapse occurred in group 3. Conclusions: Zoledronic acid has positive effects on bone formation in the sagittal suture in response to expansion and decreases the relapse ratio after expansion in rats. (Am J Orthod Dentofacial Orthop 2011; 140: e31-e41)
dc.identifier.issn0889-5406
dc.identifier.other1097-6752
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9731
dc.language.isoEnglish
dc.publisherMOSBY-ELSEVIER
dc.subjectORTHODONTIC TOOTH MOVEMENT
dc.subjectRAPID PALATAL EXPANSION
dc.subjectDISTRACTION OSTEOGENESIS
dc.subjectEXPERIMENTAL PERIODONTITIS
dc.subjectCANCER-CHEMOTHERAPY
dc.subjectMIDPALATAL SUTURE
dc.subjectFIXED APPLIANCES
dc.subjectZOLEDRONIC ACID
dc.subjectALENDRONATE
dc.subjectOSTEONECROSIS
dc.titleEffects of bisphosphonates on sutural bone formation and relapse: A histologic and immunohistochemical study
dc.typeArticle

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