Serum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction

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dc.contributor.authorGörmüş U.
dc.contributor.authorÖzmen D.
dc.contributor.authorÖzmen B.
dc.contributor.authorParildar Z.
dc.contributor.authorÖzdoǧan O.
dc.contributor.authorMutaf I.
dc.contributor.authorBayindir O.
dc.date.accessioned2025-04-10T11:15:51Z
dc.date.available2025-04-10T11:15:51Z
dc.date.issued2010
dc.description.abstractAims: : The aim of this study was to determine serum NT-proBNP and plasma Hcy levels and to explore the relationship between serum NT-proBNP and plasma Hcy levels in type 2 diabetic patients with and without asymptomatic LVDD. Methods: : NT-proBNP and Hcy levels were measured 31 patients with type 2 diabetes mellitus. According to echocardiographic data, diabetic patients were divided into two groups: normal LV function or LV diastolic dysfunction. Results: : Serum NT-proBNP levels in diabetic patients with LVDD were significantly higher than in diabetic patients with normal LV function and controls. The area under the receiver-operating characteristic (ROC) curve for NT-proBNP to separate normal vs. diastolic dysfunction was 0.96 in type 2 diabetic patients. Plasma Hcy levels were significantly higher in both diabetic groups than in controls. Positive correlation was noted between NT-proBNP and Hcy levels in diabetic patients with LVDD (r = 0.881, p = 0.0001). Conclusions: : The correlation between elevated NT-proBNP and Hcy levels in diabetic patients with LVDD suggest an association between homocysteinemia and increased NT-proBNP secretion. Our data indicate that NT-proBNP may be a simple screening tool to select diabetic patients with LVDD requiring further examination with echocardiography. © 2009 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.DOI-ID10.1016/j.diabres.2009.10.010
dc.identifier.urihttp://hdl.handle.net/20.500.14701/51329
dc.titleSerum N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) and homocysteine levels in type 2 diabetic patients with asymptomatic left ventricular diastolic dysfunction
dc.typeArticle

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