Development and validation of combined symptom-medication scores for allergic rhinitis*

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dc.contributor.authorSousa-Pinto, B
dc.contributor.authorAzevedo, LF
dc.contributor.authorJutel, M
dc.contributor.authorAgache, I
dc.contributor.authorCanonica, GW
dc.contributor.authorCzarlewski, W
dc.contributor.authorPapadopoulos, NG
dc.contributor.authorBergmann, KC
dc.contributor.authorDevillier, P
dc.contributor.authorLaune, D
dc.contributor.authorKlimek, L
dc.contributor.authorAnto, A
dc.contributor.authorAnto, JM
dc.contributor.authorEklund, P
dc.contributor.authorAlmeida, R
dc.contributor.authorBedbrook, A
dc.contributor.authorBosnic-Anticevich, S
dc.contributor.authorBrough, HA
dc.contributor.authorBrussino, L
dc.contributor.authorCardona, V
dc.contributor.authorCasale, T
dc.contributor.authorCecchi, L
dc.contributor.authorCharpin, D
dc.contributor.authorChivato, T
dc.contributor.authorCosta, EM
dc.contributor.authorCruz, AA
dc.contributor.authorDramburg, S
dc.contributor.authorDurham, SR
dc.contributor.authorDe Feo, G
dc.contributor.authorvan Wijk, RG
dc.contributor.authorFokkens, WJ
dc.contributor.authorGemicioglu, B
dc.contributor.authorHaahtela, T
dc.contributor.authorIllario, M
dc.contributor.authorIvancevich, JC
dc.contributor.authorKvedariene, V
dc.contributor.authorKuna, P
dc.contributor.authorLarenas-Linnemann, DE
dc.contributor.authorMakris, M
dc.contributor.authorMathieu-Dupas, E
dc.contributor.authorMelén, E
dc.contributor.authorMorais-Almeida, M
dc.contributor.authorMösges, R
dc.contributor.authorMullol, J
dc.contributor.authorNadeau, KC
dc.contributor.authorNhan, PH
dc.contributor.authorO'Hehir, R
dc.contributor.authorRegateiro, FS
dc.contributor.authorReitsma, S
dc.contributor.authorSamolinski, B
dc.contributor.authorSheikh, A
dc.contributor.authorStellato, C
dc.contributor.authorTodo-Bom, A
dc.contributor.authorTomazic, PV
dc.contributor.authorToppila-Salmi, S
dc.contributor.authorValero, A
dc.contributor.authorValiulis, A
dc.contributor.authorVentura, MT
dc.contributor.authorWallace, D
dc.contributor.authorWaserman, S
dc.contributor.authorYorgancioglu, A
dc.contributor.authorVries, G
dc.contributor.authorEerd, M
dc.contributor.authorZieglmayer, P
dc.contributor.authorZuberbier, T
dc.contributor.authorPfaar, O
dc.contributor.authorFonseca, JA
dc.contributor.authorBousquet, J
dc.date.accessioned2024-07-18T12:09:13Z
dc.date.available2024-07-18T12:09:13Z
dc.description.abstractBackground Validated combined symptom-medication scores (CSMSs) are needed to investigate the effects of allergic rhinitis treatments. This study aimed to use real-life data from the MASK-air(R) app to generate and validate hypothesis- and data-driven CSMSs. Methods We used MASK-air(R) data to assess the concurrent validity, test-retest reliability and responsiveness of one hypothesis-driven CSMS (modified CSMS: mCSMS), one mixed hypothesis- and data-driven score (mixed score), and several data-driven CSMSs. The latter were generated with MASK-air(R) data following cluster analysis and regression models or factor analysis. These CSMSs were compared with scales measuring (i) the impact of rhinitis on work productivity (visual analogue scale [VAS] of work of MASK-air(R), and Work Productivity and Activity Impairment: Allergy Specific [WPAI-AS]), (ii) quality-of-life (EQ-5D VAS) and (iii) control of allergic diseases (Control of Allergic Rhinitis and Asthma Test [CARAT]). Results We assessed 317,176 days of MASK-air(R) use from 17,780 users aged 16-90 years, in 25 countries. The mCSMS and the factor analyses-based CSMSs displayed poorer validity and responsiveness compared to the remaining CSMSs. The latter displayed moderate-to-strong correlations with the tested comparators, high test-retest reliability and moderate-to-large responsiveness. Among data-driven CSMSs, a better performance was observed for cluster analyses-based CSMSs. High accuracy (capacity of discriminating different levels of rhinitis control) was observed for the latter (AUC-ROC = 0.904) and for the mixed CSMS (AUC-ROC = 0.820). Conclusion The mixed CSMS and the cluster-based CSMSs presented medium-high validity, reliability and accuracy, rendering them as candidates for primary endpoints in future rhinitis trials.
dc.identifier.issn0105-4538
dc.identifier.other1398-9995
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/11124
dc.language.isoEnglish
dc.publisherWILEY
dc.subjectWORK PRODUCTIVITY
dc.subjectIMMUNOTHERAPY
dc.subjectQUESTIONNAIRE
dc.subjectRESPONSIVENESS
dc.subjectRELIABILITY
dc.subjectIMPAIRMENT
dc.subjectTRIALS
dc.subjectASTHMA
dc.subjectEQ-5D
dc.titleDevelopment and validation of combined symptom-medication scores for allergic rhinitis*
dc.typeArticle

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