Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

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dc.contributor.authorSaribas G.S.
dc.contributor.authorErdogan D.
dc.contributor.authorGoktas G.
dc.contributor.authorAkyol S.N.
dc.contributor.authorHirfanoglu I.M.
dc.contributor.authorGurgen S.G.
dc.contributor.authorCoskun N.
dc.contributor.authorOzogul C.
dc.date.accessioned2024-07-22T08:11:18Z
dc.date.available2024-07-22T08:11:18Z
dc.date.issued2016
dc.description.abstractThe aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.DOI-ID10.1080/01443615.2016.1209174
dc.identifier.issn01443615
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/15593
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAcetylcarnitine
dc.subjectAnimals
dc.subjectAntineoplastic Agents
dc.subjectCisplatin
dc.subjectFallopian Tubes
dc.subjectFemale
dc.subjectProtective Agents
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectVitamin B Complex
dc.subjectcaspase 3
dc.subjectcaspase 8
dc.subjectcaspase 9
dc.subjectcisplatin
dc.subjectlevacecarnine
dc.subjectacetylcarnitine
dc.subjectantineoplastic agent
dc.subjectcisplatin
dc.subjectprotective agent
dc.subjectvitamin B complex
dc.subjectadult
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectFallopian tube
dc.subjectfemale
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectlymphocyte
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprophylaxis
dc.subjectprotein expression
dc.subjectrat
dc.subjectsecretory cell
dc.subjecttoxicity
dc.subjectTUNEL assay
dc.subjectuterine tube disease
dc.subjectuterine tube toxicity
dc.subjectweight reduction
dc.subjectWistar rat
dc.subjectanimal
dc.subjectdrug effects
dc.subjectpathology
dc.titleExamining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity
dc.typeArticle

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