Glucose sensing employing fluorescent pH indicator

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dc.contributor.authorErtekin, K
dc.contributor.authorCinar, S
dc.contributor.authorAydemir, T
dc.contributor.authorAlp, S
dc.date.accessioned2024-07-18T11:52:08Z
dc.date.available2024-07-18T11:52:08Z
dc.description.abstractThe proton sensitive azlactone derivative; 4-[(p-N,N-dimethylamino)benzylidene]-2-phenyloxazole-5-one (DPO) exhibits high quantum yield, excellent photostability, and high molar absorptivity in a sol-gel matrix. In this work, two different DPO containing constructions were tested and evaluated as glucose sensors. In the first, both glucose oxidase (GOx) and azlactone derivative were incorporated into a single tetraethylorthosilicate (TEOS) based sol-gel phase. In the second, TEOS and 3-aminopropyltriethoxysilane (APTEOS) containing dye-doped sol-gel layer was covered with GOx entrapped sol-gel (the two-layer configuration). The monolayer configuration has the fastest response time (tau(90) = 20 s) but suffers from leaching upon prolonged use. Response time and dynamic working range of the cross-linking agent containing two-layer configuration are 40 s and 0.1-15 mM glucose, respectively. The resulting glucose sensor was characterized by high sensitivity, low interference from acidogenic species, and a working lifetime of at least 90 days. (c) 2004 Elsevier Ltd. All rights reserved.
dc.identifier.issn0143-7208
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5396
dc.language.isoEnglish
dc.publisherELSEVIER SCI LTD
dc.subjectSOL-GEL MATRIX
dc.subjectOXYGEN OPTRODE
dc.subjectBIOSENSOR
dc.subjectOXIDASE
dc.subjectSENSOR
dc.titleGlucose sensing employing fluorescent pH indicator
dc.typeArticle

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