Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet
| dc.contributor.author | Ozturk Z. | |
| dc.contributor.author | Gurpinar T. | |
| dc.contributor.author | Vural K. | |
| dc.contributor.author | Boyacioglu S. | |
| dc.contributor.author | Korkmaz M. | |
| dc.contributor.author | Var A. | |
| dc.date.accessioned | 2025-04-10T11:09:41Z | |
| dc.date.available | 2025-04-10T11:09:41Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Endothelial dysfunction develops as a result of oxidative stress and is responsible for diabetic vascular complications. We investigated the effects of selenium on endothelial dysfunction and oxidative stress in type 2 diabetic rats. Male Wistar rats were divided into five groups: controls, untreated diabetics, and diabetics treated with 180, 300, 500 mcg/kg selenium each day. Diabetes was induced by a single intraperitoneal injection of low dose streptozotocin to rats fed a high fat diet. Endothelium-dependent and-independent relaxations were measured in the thoracic aorta. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and endothelial nitric oxide synthase (eNOS) mRNA expressions were analyzed using real-time polymerase chain reaction (RT-PCR). Fasting blood glucose, lipid profile, lipid oxidation, insulin and nitric oxide were measured in blood samples. Malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase levels were measured in liver samples. RT-PCR showed that selenium reversed increased NADPH oxidase expression and decreased eNOS expression to control levels. Selenium also improved the impairment of endothelium-dependent vasorelaxation in the diabetic aorta. Selenium treatment significantly decreased blood glucose, cholesterol and triglyceride levels, and enhanced the antioxidant status in diabetic rats. Our findings suggest that selenium restores a normal metabolic profile and ameliorates vascular responses and endothelial dysfunction in diabetes by regulating antioxidant enzyme and nitric oxide release. © 2015 The Biological Stain Commission. | |
| dc.identifier.DOI-ID | 10.3109/10520295.2015.1042050 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/48921 | |
| dc.publisher | Taylor and Francis Ltd. | |
| dc.title | Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet | |
| dc.type | Article |