Effect of propofol and clonidine on cerebral blood flow velocity and carbon dioxide reactivity in the middle cerebral artery

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dc.contributor.authorMirzai, H
dc.contributor.authorTekin, I
dc.contributor.authorTarhan, S
dc.contributor.authorOk, G
dc.contributor.authorGoktan, C
dc.date.accessioned2024-07-18T11:48:45Z
dc.date.available2024-07-18T11:48:45Z
dc.description.abstractThis study was designed to evaluate the effects of propofol alone and propofol-clonidine combination on human middle cerebral artery blood flow velocity (Vmca) and cerebrovascular carbon dioxide (CO,) response by using transcranial Doppler ultrasonography. Mean Vmca in response to changes in arterial partial pressure of CO2 (Paco(2)) was determined under the following conditions: awake (group 1), propofol anesthesia (group 2), and combined propofolclonidine anesthesia (group 3). Nonnocapnic, hypercapnic, and hypocapnic values of heart rate, mean arterial pressure, partial end-tidal CO2 pressure, Paco(2), and Vmca were obtained. The mean Vmca in groups 2 and 3 was significantly lower than that in group 1 at each level of Paco(2). The calculated Vmca at each level of Paco(2) was not different between groups 2 and 3. There was a correlation between Paco(2), and Vmca in all groups, but in the anesthetized groups the effect of Paco(2) on Vinca was attenuated. The present data demonstrated that clonidine-propofol does not change CO2 reactivity compared with propofol alone, but both anesthetics attenuate cerebral blood flow compared with awake controls.
dc.identifier.issn0898-4921
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3475
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectCO2 REACTIVITY
dc.subjectDEXMEDETOMIDINE
dc.subjectPRESSURE
dc.subjectANESTHESIA
dc.subjectAGONIST
dc.subjectVOLUME
dc.subjectHUMANS
dc.subjectOXIDE
dc.subjectRATS
dc.subjectDOG
dc.titleEffect of propofol and clonidine on cerebral blood flow velocity and carbon dioxide reactivity in the middle cerebral artery
dc.typeArticle

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