Effectiveness of montelukast in pediatric patients with allergic rhinitis

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dc.contributor.authorYilmaz, O
dc.contributor.authorAltintas, D
dc.contributor.authorRondon, C
dc.contributor.authorCingi, C
dc.contributor.authorOghan, F
dc.date.accessioned2024-07-18T12:05:58Z
dc.date.available2024-07-18T12:05:58Z
dc.description.abstractAllergic rhinitis (AR) is one of the most common chronic diseases of childhood and carries significant morbidity as well as physical and psychosocial consequences. Therapy aims to alleviate clinical symptoms, prevent complications and improve psychosocial consequences. Leukotrienes which are amongst the main mediators in pathogenesis of AR have chemotactic properties and lead to increased vascular permeability. Thus, leukotriene antagonism may be an effective therapeutic option in treatment of allergic diseases, specifically AR. Montelukast which is a leukotriene receptor type I inhibitor has variable efficacy in children with AR and the guidelines recommend its use in children with seasonal AR aged six years and above. Although its efficacy is inferior to anti-histamines and intranasal corticosteroids, combination treatment may warrant clinical efficacy. Therefore, montelukast may be considered to be a well-tolerated therapeutic option for children with AR with minor side effects though long term results need to be assessed. In conclusion, larger scale research enrolling pediatric cases with seasonal and persistent AR are required before concise recommendations about montelukast use in pediatric AR can be made. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.issn0165-5876
dc.identifier.other1872-8464
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10101
dc.language.isoEnglish
dc.publisherELSEVIER IRELAND LTD
dc.subjectLEUKOTRIENE RECEPTOR ANTAGONIST
dc.subjectEXHALED NITRIC-OXIDE
dc.subjectCLINICAL-TRIALS
dc.subjectSCHOOL-AGE
dc.subjectCHILDREN
dc.subjectASTHMA
dc.subjectPREVALENCE
dc.subjectSCHOOLCHILDREN
dc.subjectTOLERABILITY
dc.subjectCETIRIZINE
dc.titleEffectiveness of montelukast in pediatric patients with allergic rhinitis
dc.typeReview

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