Synthesis and antimicrobial evaluation of sulfanilamide- and carbohydrate-derived 1,4-disubstitued-1,2,3-triazoles via click chemistry

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dc.contributor.authorAy, K
dc.contributor.authorIspartaloglu, B
dc.contributor.authorHalay, E
dc.contributor.authorAy, E
dc.contributor.authorYasa, I
dc.contributor.authorKarayildirim, T
dc.date.accessioned2024-07-18T12:05:31Z
dc.date.available2024-07-18T12:05:31Z
dc.description.abstract4-Sulfanilamido substitued-1,2,3-triazoles conjugated with monosaccharides (8-17) including d-glucose, d-galactose, d-mannose, and d-fructose were synthesized in good yields from azidosugars with propargyl sulfanilamides using copper catalyst 1,3-dipolar cycloaddition reaction (CuAAC). The structures of new compounds were elucidated by liquid chromatography-mass spectrometry, infrared, one-dimensional- and two-dimensional-nuclear magnetic resonance techniques. All of the new compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhimurium, Klebsiella pneumoniae, Enterococcus faecalis, Pseudomonas aeruginosa, and Candida albicans for their antibacterial and antifungal activities. Experimental results showed antimicrobial activity with minimum inhibitory concentrations values a ranging from 0.078 to 5.0 mg/mL against test microorganisms.
dc.identifier.issn1054-2523
dc.identifier.other1554-8120
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9822
dc.language.isoEnglish
dc.publisherSPRINGER BIRKHAUSER
dc.subjectCARBONIC-ANHYDRASE INHIBITORS
dc.subjectANTIFUNGAL ACTIVITY
dc.subjectBIOLOGICAL-ACTIVITY
dc.subject1,2,3-TRIAZOLE
dc.subjectANALOGS
dc.subjectDERIVATIVES
dc.subjectTRIAZOLES
dc.subjectALKYNES
dc.subjectDESIGN
dc.titleSynthesis and antimicrobial evaluation of sulfanilamide- and carbohydrate-derived 1,4-disubstitued-1,2,3-triazoles via click chemistry
dc.typeArticle

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