Effect of selective gut decontamination on peritoneal fibrinolytic activity in rats
| dc.contributor.author | Ilkul, Ö | |
| dc.contributor.author | Erhan, Y | |
| dc.contributor.author | Aydede, H | |
| dc.contributor.author | Var, A | |
| dc.contributor.author | Onur, E | |
| dc.date.accessioned | 2024-07-18T11:47:16Z | |
| dc.date.available | 2024-07-18T11:47:16Z | |
| dc.description.abstract | Purpose: Our goal with this experiment was to determine the influence of selective decontamination of the digestive tract (SDD) on peritoneal fibrinolytic activity in rats. Materials and Methods: Animals were divided into five groups. Group 1 was subjected to SDD-treated peritoneal adhesion. Group 2 was subjected only to perioneal adhesion. Group 3 was SDD-treated, whereas Group 4 was labeled as the control group. Group 5 was subjected to simple laparotomy. The rats in Group 1 and Group 3 were given SDD (tobramycin 20 mg/l and polymyxin E 25 mg/l) by gavage twice daily for 3 days preceding surgical operation. Control groups were fed orally with standard chow. After a 72-hour waiting period following the operation, biopsies of undamaged parietal peritoneum were obtained from the fibrinolytic parameters in order to measure tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1). Results: Average tPA levels were low in both the sdd-treated group and the sdd+ adhesion model group, however no statistical significance was elicited. PAI-1 levels were higher in sdd-treated groups than in other groups, but no significantly meaningful difference was obtained. Conclusion: These results suggest that pretreatment with sdd reduces the peritoneal fibrinolytic activity and might also enhance the peritoneal adhesion formation in rats. | |
| dc.identifier.issn | 2564-6850 | |
| dc.identifier.other | 2564-7032 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3392 | |
| dc.language.iso | Turkish | |
| dc.publisher | AVES | |
| dc.title | Effect of selective gut decontamination on peritoneal fibrinolytic activity in rats | |
| dc.type | Article |