TRP Channels in Tension-Type Headache: A Pilot Study; [Gerilim Tipi Baş Ağrısında TRP Kanalları: Pilot Çalışma]

Simple item page
dc.contributor.authorGemici Y.İ.
dc.contributor.authorTaşcı İ.
dc.contributor.authorDurmuş K.
dc.contributor.authorKoç A.
dc.date.accessioned2024-07-22T08:06:26Z
dc.date.available2024-07-22T08:06:26Z
dc.date.issued2021
dc.description.abstractTension-type headache (TTH) affects many individuals worldwide. Although the exact pathogenesis of TTH remains unclear, central, and peripheral mechanisms are considered to play a role in TTH 1. This pilot study aimed to investigate the role of transient receptor potential (TRP) channels in the development or chronic inflammation in TTH and to discuss the findings in the light of literature. This pilot study included a patient group comprising three patients with episodic TTH and three patients with chronic TTH (CTTH) aged 18-40 years with no comorbidities and a control group of three patients with no headache. Peripheral blood samples were obtained from all the participants, and both RNA and cDNA were isolated on the same day. The mRNA levels of pain-related TRP channels [TRPA1, TRP vanilloid-1 (TRPV1), TRPV3, TRPV4, TRPM3, and TRPM8] were measured by reverse transcriptase (RT)-quantititave polymerase chain reaction method and were normalized with the levels of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) transcript. Results were analyzed using statistical methods. All three groups were comparable with regard to demographic characteristics. No significant difference was found among the groups with regard to the mRNA levels of the TRP channels normalized by GAPDH, whereas the TRPM8 expression levels were not significantly lower in the CTTH group than in other groups (p=0.066). This study revealed that TRPM8 is likely to have a role in the pathogenesis of TTH, and this role of TRPM8 may be investigated by further studies. © 2021 by Turkish Neurological Society Turkish Journal of Neurology published by Galenos Publishing House.
dc.identifier.DOI-ID10.4274/TND.2021.26879
dc.identifier.issn1301062X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13525
dc.language.isoEnglish
dc.publisherTurkish Neurosurgical Society
dc.rightsAll Open Access; Gold Open Access
dc.subjectcomplementary DNA
dc.subjectglyceraldehyde 3 phosphate dehydrogenase
dc.subjectRNA directed DNA polymerase
dc.subjecttransient receptor potential channel
dc.subjecttransient receptor potential channel A1
dc.subjecttransient receptor potential channel M8
dc.subjectvanilloid receptor 1
dc.subjectvanilloid receptor 3
dc.subjectvanilloid receptor 4
dc.subjectadult
dc.subjectArticle
dc.subjectchronic tension headache
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcomorbidity
dc.subjectDNA methylation
dc.subjectfemale
dc.subjectgene amplification
dc.subjectgene expression
dc.subjectgenetic transcription
dc.subjectgenotype
dc.subjecthuman
dc.subjectmale
dc.subjectmRNA expression level
dc.subjectnausea and vomiting
dc.subjectphotophobia
dc.subjectpilot study
dc.subjectreal time polymerase chain reaction
dc.subjectRNA extraction
dc.subjecttension headache
dc.titleTRP Channels in Tension-Type Headache: A Pilot Study; [Gerilim Tipi Baş Ağrısında TRP Kanalları: Pilot Çalışma]
dc.typeArticle

Files

Collections

Scopus Koleksiyonu