Prevalence of the angiotensin i converting enzyme gene insertion/deletion polymorphism in a healthy turkish population
| dc.contributor.author | Berdeli A. | |
| dc.contributor.author | Cam F.S. | |
| dc.date.accessioned | 2025-04-10T11:16:08Z | |
| dc.date.available | 2025-04-10T11:16:08Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations. © 2009 Springer Science+Business Media, LLC. | |
| dc.identifier.DOI-ID | 10.1007/s10528-009-9240-8 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/51568 | |
| dc.title | Prevalence of the angiotensin i converting enzyme gene insertion/deletion polymorphism in a healthy turkish population | |
| dc.type | Article |