Association between uterine leiomyoma and fragmented QRS waves: a prospective case-control study
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2024
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Abstract
OBJECTIVE: The aim of this study was to evaluate the relationship between uterine leiomyoma and fragmented QRS, a non-invasive indicator of cardiovascular risk and myocardial ischemia, in women with uterine leiomyoma. METHODS: In this prospective case-control study, a total of 47 patients diagnosed with uterine leiomyoma (case group) and 47 healthy individuals without uterine leiomyoma (control group) who had undergone bilateral tubal ligation surgery were included. Various demographic, clinical, and laboratory parameters and the presence of fragmented QRS were recorded. RESULTS: The leiomyoma group showed significantly higher body mass index (27.46±2.18 vs. 25.9±2.87 kg/m2, p=0.005) and waist circumference (91.34±9.30 vs. 84.97±9.3 cm, p=0.001) compared with the control group. Uterine volumes were also significantly higher in the leiomyoma group (235.75±323.48 vs. 53.24±12.81 mm3, p<0.001). The presence of fragmented QRS was detected in 18.1% of the patients. Multiple regression analysis identified age, fasting blood glucose value, and the presence of fragmented QRS as independent risk factors for the presence of leiomyoma. CONCLUSION: This study provides valuable insights into the relationship between uterine leiomyoma and fragmented QRS. The presence of fragmented QRS was identified as an independent risk factor for the presence of leiomyoma. Further research is needed to better understand the underlying mechanisms connecting uterine leiomyoma and cardiovascular health. © 2024 Associacao Medica Brasileira. All rights reserved.
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Adult , Body Mass Index , Case-Control Studies , Electrocardiography , Female , Humans , Leiomyoma , Middle Aged , Myocardial Ischemia , Prospective Studies , Risk Factors , Uterine Neoplasms , alanine aminotransferase , aspartate aminotransferase , cholesterol , creatinine , estradiol , follitropin , glucose , hemoglobin , hemoglobin A1c , high density lipoprotein cholesterol , insulin , low density lipoprotein cholesterol , luteinizing hormone , triacylglycerol , very low density lipoprotein cholesterol , abdominal circumference , adult , Article , blood cell count , body mass , cardiovascular risk , case control study , cesarean section , clinical article , clinical trial , cohort analysis , controlled study , electrocardiography , endometrial thickness , female , glucose blood level , heart muscle ischemia , heart rate , hematocrit , homeostasis model assessment , human , leiomyoma , leukocyte count , parity , physical examination , platelet count , pregnancy , prospective study , QRS interval , risk factor , urea nitrogen blood level , uterine tube ligation , uterus myoma , waist circumference , complication , electrocardiography , leiomyoma , middle aged , pathophysiology , prospective study , uterus tumor