The effect of an eight-week walking program on bone turnover markers and sRANKL/osteoprotegerin levels in post-menopausal women; [Sekiz haftalik yürüme programinin menopoz sonrasi kadinlarda kemik döngüsügöstergeleri ve sRANKL/osteoprotegerin düzeyleri üzerine etkisi]

Büyükyazi G.

The effect of an eight-week walking program on bone turnover markers and sRANKL/osteoprotegerin levels in post-menopausal women; [Sekiz haftalik yürüme programinin menopoz sonrasi kadinlarda kemik döngüsügöstergeleri ve sRANKL/osteoprotegerin düzeyleri üzerine etkisi]

Date

2009

Authors

Büyükyazi G.

Publisher

Turkiye Klinikleri

Abstract

Objective: To examine the effect of an eight-week moderate intensity walking program on bone turnover markers, serum osteoprotegerin (OPG) and soluble receptor-activator of nuclear factor- kappa β ligand (sRANKL) in postmenopausal women. Material and Methods: Twelve postmenopausal women (45-62 years) completed an eight-week walking program at moderate intensity (60-65% maximum heart rate reserve). Non-walking women served as the control group (CG; n= 11). Body weight, percent body fat, body mass index (BMI), estimated maximal oxygen consumption (estimated VO2max), bone turnover markers, sRANKL, serum OPG and sRANKL/OPG ratio were measured before and after the intervention. Results: Eight-week walking program produced significant increases in VO 2max and reductions in body weight and BMI. Serum intact parathyroid hormone (iPTH), and β- crosslaps (CTx) reduced (p< 0.01, for both), sRANKL/OPG ratio (p< 0.01) and sRANKL values (p< 0.05) increased in the exercise group (EG). We detected significant reductions in the serum OPG levels of EG and CG (p< 0.01). No significant differences were observed between the changes in EG and CG in terms of bone turnover markers, OPG and sRANKL values. Conclusion: Eight-week moderate intensity walking program is beneficial for improving cardiorespiratory function in postmenopausal women to enable them to lead a less risky and a more independent life; however, it seems not so effective in changing the bone turnover markers and the OPG/sRANKL system. Copyright © 2009 by Türkiye Klinikleri.