Effects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet

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dc.contributor.authorOztürk, Z
dc.contributor.authorGurpinar, T
dc.contributor.authorVural, K
dc.contributor.authorBoyacioglu, SÖ
dc.contributor.authorKorkmaz, M
dc.contributor.authorVar, A
dc.date.accessioned2024-07-18T11:54:21Z
dc.date.available2024-07-18T11:54:21Z
dc.description.abstractEndothelial dysfunction develops as a result of oxidative stress and is responsible for diabetic vascular complications. We investigated the effects of selenium on endothelial dysfunction and oxidative stress in type 2 diabetic rats. Male Wistar rats were divided into five groups: controls, untreated diabetics, and diabetics treated with 180, 300, 500 mcg/kg selenium each day. Diabetes was induced by a single intraperitoneal injection of low dose streptozotocin to rats fed a high fat diet. Endothelium-dependent and -independent relaxations were measured in the thoracic aorta. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and endothelial nitric oxide synthase (eNOS) mRNA expressions were analyzed using real-time polymerase chain reaction (RT-PCR). Fasting blood glucose, lipid profile, lipid oxidation, insulin and nitric oxide were measured in blood samples. Malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase levels were measured in liver samples. RT-PCR showed that selenium reversed increased NADPH oxidase expression and decreased eNOS expression to control levels. Selenium also improved the impairment of endothelium-dependent vasorelaxation in the diabetic aorta. Selenium treatment significantly decreased blood glucose, cholesterol and triglyceride levels, and enhanced the antioxidant status in diabetic rats. Our findings suggest that selenium restores a normal metabolic profile and ameliorates vascular responses and endothelial dysfunction in diabetes by regulating antioxidant enzyme and nitric oxide release.
dc.identifier.issn1052-0295
dc.identifier.other1473-7760
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6270
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectNITRIC-OXIDE SYNTHASE
dc.subjectOXIDATIVE STRESS
dc.subjectGENE-EXPRESSION
dc.subjectANTIOXIDANT
dc.subjectINSULIN
dc.subjectSUPPLEMENTATION
dc.subjectCOMBINATION
dc.subjectGLUCOSE
dc.subjectKINASE
dc.subjectMEN
dc.titleEffects of selenium on endothelial dysfunction and metabolic profile in low dose streptozotocin induced diabetic rats fed a high fat diet
dc.typeArticle

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