C-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression
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Date
2022
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Abstract
Context: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis. Subjects and Methods: After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver in situ hybridization/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows. Results: c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (P = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (P = 0.016). Conclusions: Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab. © 2022 Chinese Journal of Physiology.
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Carcinoma , Gene Expression , Humans , Immunohistochemistry , In Situ Hybridization , Receptor, ErbB-2 , Stomach Neoplasms , epidermal growth factor receptor 2 , scatter factor receptor , trastuzumab , epidermal growth factor receptor 2 , adenocarcinoma , adult , aged , anastomosis , Article , cancer prognosis , chromosome 17 , colloid carcinoma , comparative study , controlled study , depth of invasion , distant metastasis , female , gastric localization , gene expression , gene locus , gene overexpression , her2 gene , histology , histopathology , human , human epidermal growth factor receptor 2 negative breast cancer , human epidermal growth factor receptor 2 positive breast cancer , human tissue , immunohistochemistry , in situ hybridization , intracellular signaling , lymph node metastasis , lymph vessel metastasis , major clinical study , male , oncogene , pathology , perineural invasion , randomized controlled trial , silver in situ hybridization , stomach carcinoma , survival rate , tumor localization , tumor volume , carcinoma , gene expression , genetics , stomach tumor