C-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression

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dc.contributor.authorCoskun F.
dc.contributor.authorAyhan S.
dc.contributor.authorTan A.
dc.contributor.authorIsisag A.
dc.date.accessioned2024-07-22T08:03:57Z
dc.date.available2024-07-22T08:03:57Z
dc.date.issued2022
dc.description.abstractContext: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis. Subjects and Methods: After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver in situ hybridization/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows. Results: c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (P = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (P = 0.016). Conclusions: Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab. © 2022 Chinese Journal of Physiology.
dc.identifier.DOI-ID10.4103/ijpm.ijpm_23_21
dc.identifier.issn03774929
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/12500
dc.language.isoEnglish
dc.publisherWolters Kluwer Medknow Publications
dc.subjectCarcinoma
dc.subjectGene Expression
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectIn Situ Hybridization
dc.subjectReceptor, ErbB-2
dc.subjectStomach Neoplasms
dc.subjectepidermal growth factor receptor 2
dc.subjectscatter factor receptor
dc.subjecttrastuzumab
dc.subjectepidermal growth factor receptor 2
dc.subjectadenocarcinoma
dc.subjectadult
dc.subjectaged
dc.subjectanastomosis
dc.subjectArticle
dc.subjectcancer prognosis
dc.subjectchromosome 17
dc.subjectcolloid carcinoma
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdepth of invasion
dc.subjectdistant metastasis
dc.subjectfemale
dc.subjectgastric localization
dc.subjectgene expression
dc.subjectgene locus
dc.subjectgene overexpression
dc.subjecther2 gene
dc.subjecthistology
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman epidermal growth factor receptor 2 negative breast cancer
dc.subjecthuman epidermal growth factor receptor 2 positive breast cancer
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectin situ hybridization
dc.subjectintracellular signaling
dc.subjectlymph node metastasis
dc.subjectlymph vessel metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoncogene
dc.subjectpathology
dc.subjectperineural invasion
dc.subjectrandomized controlled trial
dc.subjectsilver in situ hybridization
dc.subjectstomach carcinoma
dc.subjectsurvival rate
dc.subjecttumor localization
dc.subjecttumor volume
dc.subjectcarcinoma
dc.subjectgene expression
dc.subjectgenetics
dc.subjectstomach tumor
dc.titleC-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression
dc.typeArticle

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