Nasal mucosal expression of nitric oxide synthases in patients with allergic relation to asthma rhinitis and its

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dc.contributor.authorYuksel, H
dc.contributor.authorKirmaz, C
dc.contributor.authorYilmaz, O
dc.contributor.authorPinar, E
dc.contributor.authorVatansever, S
dc.contributor.authorDegirmenci, PB
dc.contributor.authorOzbilgin, K
dc.date.accessioned2024-07-18T11:47:21Z
dc.date.available2024-07-18T11:47:21Z
dc.description.abstractBackground: Nitric oxide (NO) has contradictory roles in the pathophysiology of allergic inflammation in both allergic rhinitis (AR) and asthma. Small amounts of NO produced by constitutive NO synthase (NOS) is anti-inflammatory, whereas large amounts produced by inducible NOS (iNOS) are proinflammatory. Objective: To investigate the difference in constitutive endothelial NOS (eNOS) and iNOS expression in nonallergic and allergic mucosa and the possible relation of this to the coexistence of asthma in seasonal AR. Methods: Seventeen patients (10 women and 7 men) with seasonal AR and 9 nonallergic patients (5 women and 4 men) with nasal septum deviation were enrolled. Inferior turbinate nasal biopsy specimens were obtained in all. Levels of eNOS and iNOS expressed as immunohistochemical scores (HSCOREs) were determined immunohistochemically from the specimens. Results: The mean +/- SD HSCOREs for eNOS in patients with seasonal AR were not significantly different from those of the nonallergic controls (1.85 +/- 0.78 vs 1.63 +/- 0.54; P =.12). On the other hand, the mean SD HSCOREs for iNOS were significantly higher in patients with seasonal AR (1.75 +/- 0.75 vs 0.71 +/- 0.6; P =.004). Furthermore, although eNOS expression was not different between seasonal AR patients with and without asthma, the mean +/- SD HSCOREs for iNOS were significantly higher in the patients with asthma (1.93 +/- 0.78 vs 1.65 +/- 0.55; P =.01). Conclusion: Increased expression of iNOS might have a role in the development of allergic inflammation in upper and lower airways and in comorbidity of AR and asthma.
dc.identifier.issn1081-1206
dc.identifier.other1534-4436
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3466
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE INC
dc.subjectAIRWAY HYPERRESPONSIVENESS
dc.subjectINFLAMMATION
dc.subjectIMPACT
dc.titleNasal mucosal expression of nitric oxide synthases in patients with allergic relation to asthma rhinitis and its
dc.typeArticle

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