Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: Prospective animal study
| dc.contributor.author | Malkoc G. | |
| dc.contributor.author | Dalgic A. | |
| dc.contributor.author | Koc M. | |
| dc.contributor.author | Kandogan T. | |
| dc.contributor.author | Korkmaz S. | |
| dc.contributor.author | Ceylan M.E. | |
| dc.contributor.author | Inan S. | |
| dc.contributor.author | Olgun L. | |
| dc.date.accessioned | 2025-04-10T11:12:32Z | |
| dc.date.available | 2025-04-10T11:12:32Z | |
| dc.date.issued | 2014 | |
| dc.description.abstract | Objective: This study aimed to present the histopathological and audiological effects of mechanical trauma associated with the placement of a model electrode in the scala tympani in rats, and the effects of continuous topical corticosteroid application. Method: The study comprised three groups of rats. The round window membrane was perforated in all three groups and a model electrode was inserted in the round window. Group one received no further treatments. Groups two and three also had an intrathecal microcatheter compatible with a mini-osmotic pump inserted; in group two this was used to release normal saline and in group three the pump released 400 μg/ml dexamethasone. Results: Dexamethasone infusion given after implantation of the intracochlear model electrode was more effective for preventing hearing loss than the administration of just one dose of dexamethasone. Conclusion: The findings suggest that continuous dexamethasone infusion is beneficial for preventing the loss of hair cells and neurons associated with early and late periods of intracochlear electrode trauma. Copyright © JLO (1984) Limited 2014. | |
| dc.identifier.DOI-ID | 10.1017/S002221511400156X | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/49642 | |
| dc.title | Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: Prospective animal study | |
| dc.type | Article |