Plasma levels of antioxidant vitamins in patients with acromegaly: A case-control study
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Date
2019
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Abstract
OBJECTIVE: The aim of this study was to compare antioxidant Vitamin C and Vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. MATERIAL AND METHODS: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6±9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p <0.001). Vitamin E levels didn't show a significant difference between the acromegaly and the control groups (14.2±3.6 vs. 14.8±3.7, as mean±SD, respectively, p = 0.439). Correlation analysis showed that Vitamin C levels were not significantly associated with clinical, anthropometric and laboratory parameters in the acromegaly group. Vitamin E levels were significantly associated with the total cholesterol, triglyceride, LDL-C, HDL-C, APO Al, APO B both in the acromegaly and the control groups. CONCLUSION: This study is the first one to investigate the relationship between the levels of Vitamin C & E and anthropometric & metabolic parameters in acromegaly patients and control group. In our study, Vitamin C level was significantly lower in the acromegaly group compared to the level in the control group. There was no significant difference in Vitamin E levels between the acromegaly and control group. © 2019 Maghira and Maas Publications. All rights reserved.
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Acromegaly , Adipose Tissue , Adult , Apolipoprotein A-I , Apolipoproteins B , Ascorbic Acid , Body Composition , Body Mass Index , Case-Control Studies , Cholesterol , Cholesterol, HDL , Cholesterol, LDL , Electric Impedance , Female , Human Growth Hormone , Humans , Insulin Resistance , Insulin-Like Growth Factor I , Male , Middle Aged , Receptors, Somatotropin , Triglycerides , Vitamin E , Waist Circumference , alpha tocopherol , apolipoprotein A1 , apolipoprotein B , ascorbic acid , cholesterol , high density lipoprotein cholesterol , low density lipoprotein cholesterol , pegvisomant , triacylglycerol , alpha tocopherol , apolipoprotein A1 , apolipoprotein B , ascorbic acid , cholesterol , growth hormone receptor , high density lipoprotein cholesterol , human growth hormone , low density lipoprotein cholesterol , pegvisomant , somatomedin C , triacylglycerol , acromegaly , adult , anthropometric parameters , Article , case control study , cholesterol blood level , clinical feature , controlled study , correlation analysis , diabetes mellitus , disease duration , female , glucose intolerance , high performance liquid chromatography , human , hypertension , impaired glucose tolerance , impedance , laboratory test , major clinical study , male , medical history , metabolic parameters , patient , remission , smoking , triacylglycerol blood level , vitamin blood level , acromegaly , adipose tissue , blood , body composition , body mass , insulin resistance , metabolism , middle aged , waist circumference