Plasma levels of antioxidant vitamins in patients with acromegaly: A case-control study

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dc.contributor.authorKutbay N.O.
dc.contributor.authorYurekli B.S.
dc.contributor.authorSimsir I.Y.
dc.contributor.authorSuner A.
dc.contributor.authorSeckiner S.
dc.contributor.authorKucukerdonmez O.
dc.contributor.authorSaygili F.
dc.date.accessioned2024-07-22T08:08:59Z
dc.date.available2024-07-22T08:08:59Z
dc.date.issued2019
dc.description.abstractOBJECTIVE: The aim of this study was to compare antioxidant Vitamin C and Vitamin E levels in the non-acromegaly control group and in patients with acromegaly with and without remission. MATERIAL AND METHODS: In this study, 100 cases, acromegaly patients of 57% (n=57, 29F, 28M, mean ages of 49.5±12.1) and control subjects of 43% (n=43, 29F, 14M, mean ages of 49.6±9.2). Acromegaly patients were classified into two groups; active acromegaly (AA; n=33) and controlled acromegaly (CA; n=24). RESULTS: Vitamin C levels were significantly lower in the acromegaly group [7.6 (4.7) mg/L, as median (IQR)] when compared to the control group [12.2 (5.5) mg/L, as median (IQR)] (p <0.001). Vitamin E levels didn't show a significant difference between the acromegaly and the control groups (14.2±3.6 vs. 14.8±3.7, as mean±SD, respectively, p = 0.439). Correlation analysis showed that Vitamin C levels were not significantly associated with clinical, anthropometric and laboratory parameters in the acromegaly group. Vitamin E levels were significantly associated with the total cholesterol, triglyceride, LDL-C, HDL-C, APO Al, APO B both in the acromegaly and the control groups. CONCLUSION: This study is the first one to investigate the relationship between the levels of Vitamin C & E and anthropometric & metabolic parameters in acromegaly patients and control group. In our study, Vitamin C level was significantly lower in the acromegaly group compared to the level in the control group. There was no significant difference in Vitamin E levels between the acromegaly and control group. © 2019 Maghira and Maas Publications. All rights reserved.
dc.identifier.issn0172780X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14595
dc.language.isoEnglish
dc.publisherMaghira and Maas Publications
dc.subjectAcromegaly
dc.subjectAdipose Tissue
dc.subjectAdult
dc.subjectApolipoprotein A-I
dc.subjectApolipoproteins B
dc.subjectAscorbic Acid
dc.subjectBody Composition
dc.subjectBody Mass Index
dc.subjectCase-Control Studies
dc.subjectCholesterol
dc.subjectCholesterol, HDL
dc.subjectCholesterol, LDL
dc.subjectElectric Impedance
dc.subjectFemale
dc.subjectHuman Growth Hormone
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectInsulin-Like Growth Factor I
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectReceptors, Somatotropin
dc.subjectTriglycerides
dc.subjectVitamin E
dc.subjectWaist Circumference
dc.subjectalpha tocopherol
dc.subjectapolipoprotein A1
dc.subjectapolipoprotein B
dc.subjectascorbic acid
dc.subjectcholesterol
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlow density lipoprotein cholesterol
dc.subjectpegvisomant
dc.subjecttriacylglycerol
dc.subjectalpha tocopherol
dc.subjectapolipoprotein A1
dc.subjectapolipoprotein B
dc.subjectascorbic acid
dc.subjectcholesterol
dc.subjectgrowth hormone receptor
dc.subjecthigh density lipoprotein cholesterol
dc.subjecthuman growth hormone
dc.subjectlow density lipoprotein cholesterol
dc.subjectpegvisomant
dc.subjectsomatomedin C
dc.subjecttriacylglycerol
dc.subjectacromegaly
dc.subjectadult
dc.subjectanthropometric parameters
dc.subjectArticle
dc.subjectcase control study
dc.subjectcholesterol blood level
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdiabetes mellitus
dc.subjectdisease duration
dc.subjectfemale
dc.subjectglucose intolerance
dc.subjecthigh performance liquid chromatography
dc.subjecthuman
dc.subjecthypertension
dc.subjectimpaired glucose tolerance
dc.subjectimpedance
dc.subjectlaboratory test
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectmetabolic parameters
dc.subjectpatient
dc.subjectremission
dc.subjectsmoking
dc.subjecttriacylglycerol blood level
dc.subjectvitamin blood level
dc.subjectacromegaly
dc.subjectadipose tissue
dc.subjectblood
dc.subjectbody composition
dc.subjectbody mass
dc.subjectinsulin resistance
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectwaist circumference
dc.titlePlasma levels of antioxidant vitamins in patients with acromegaly: A case-control study
dc.typeArticle

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