Polikistik Over Sendromlu ve Normal Menstrüel Sikluslu Kadınlarda İnsülin Duyarlılığı Düzeylerinin Kıyaslanması
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Date
2017
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Abstract
Aim: Although pathophysiology of polycystic ovary syndrome(PCOS) has not been fully understood, it has been suggested thatdecreasing insulin sensitivity may have a pivotal role in this disorder.In this study it was aimed that as a non invasive technique, quantitativeinsulin sensitivity check index-(QUICKI) levels which has reflectedthe insulin sensitivity status, were compared in women withPCOS and regular menses. Additionally, we evaluated whether thisindex may have been used in clinical practice of PCOS.Material and Method: Fifty women with PCOS and fifty age and bodymass index matched healthy women with regular menses were retrospectivelyevaluated. Serum fasting glucose, insulin and testosteroneconcentrations were assessed. QUICKI and homeostasis model assessmentof insulin resistance (HOMA-IR) indice was calculated.Results: There were no significant differences in between twogroups according to both QUICKI (PCOS group=0.329±0.022vs. Control group=0.333±0.019; p=0.39) and HOMA-IR (PCOSgroup=3.057±1.468 vs. Control group=2.717±1.037; p=0.184).QUICKI was not significantly correlated with glucose (p=0.136)and testosterone levels (p=0.227), whereas significantly negativecorrelated with both insulin (r=-0.925, p<0.001), and HOMA-IR(r=-0.95, p<0.001).Conclusion: Insulin sensitivity which should be appreciated aclinical condition in women with PCOS. In our country reliablereference ranges of insulin sensitivity/resistance status in PCOSstill have not avaible. Therefore, it was suggested that advancedstudies should prospectively execute the cut of values of insulinsensitivity in PCOS.